NAD-dependent protein deacetylase HST2 (HST2) is a 357-residue protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c). This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P53686.
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The mean pLDDT of this model is 84.8 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 63% |
| 70 to 90 | Confident: backbone generally right | 21% |
| 50 to 70 | Low: treat with caution | 5% |
| Below 50 | Very low: often disordered regions | 12% |
What pLDDT means and how to read it
NAD-dependent histone deacetylase that is involved in nuclear silencing events. Derepresses subtelomeric silencing and increases repression in nucleolar (rDNA) silencing. Its function is negatively regulated by active nuclear export
Homotrimer. Monomer. Homotrimeric in its unliganded state. Undergoes a trimer-monomer transition upon acetyl-lysine substrate binding
Cytoplasm, Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 1Q1A | X-ray | 1.5 Å | A=5-293 |
| 1SZD | X-ray | 1.5 Å | A=1-294 |
| 1SZC | X-ray | 1.75 Å | A=1-294 |
| 7F4E | X-ray | 1.78 Å | A=8-294 |
| 7F51 | X-ray | 1.98 Å | A=8-294 |
| 2OD2 | X-ray | 2.0 Å | A=1-294 |
| 2OD7 | X-ray | 2.0 Å | A=1-294 |
| 2QQF | X-ray | 2.0 Å | A=1-294 |
| 2OD9 | X-ray | 2.05 Å | A=1-294 |
| 2QQG | X-ray | 2.05 Å | A=1-294 |
| 1Q14 | X-ray | 2.5 Å | A=1-357 |
| 1Q17 | X-ray | 2.7 Å | A/B/C=1-294 |
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