Ephrin type-A receptor 4 (EPHA4) is a 986-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P54764.
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The mean pLDDT of this model is 83.5 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 54% |
| 70 to 90 | Confident: backbone generally right | 31% |
| 50 to 70 | Low: treat with caution | 5% |
| Below 50 | Very low: often disordered regions | 10% |
What pLDDT means and how to read it
Receptor tyrosine kinase which binds membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous, it has the unique property among Eph receptors to bind and to be physiologically activated by both GPI-anchored ephrin-A and transmembrane ephrin-B ligands including EFNA1 and EFNB3. Upon activation by ephrin ligands, modulates cell morphology and integrin-dependent cell adhesion through regulation of the Rac, Rap…
Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer and a receptor dimer. Oligomerization is probably required to induce biological responses. Interacts (phosphorylated at position Tyr-602) with FYN. Interacts with CDK5, CDK5R1 and NGEF; upon activation by EFNA1 induces NGEF phosphorylation by the kinase CDK5. Interacts with CHN1; effector of EPHA4 in…
Cell membrane, Cell projection, axon, Cell projection, dendrite, Postsynaptic density membrane, Early endosome, Cell junction, adherens junction
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7OFV | X-ray | 1.43 Å | A=29-209 |
| 5JR2 | X-ray | 1.75 Å | A/B/C/D=29-204 |
| 2WO1 | X-ray | 1.85 Å | A/B=30-202 |
| 4M4P | X-ray | 2.08 Å | A=27-543 |
| 2WO3 | X-ray | 2.35 Å | A=30-202 |
| 4W4Z | X-ray | 2.41 Å | A/B/C/D=29-204 |
| 4W50 | X-ray | 2.42 Å | A/B/C/D=29-204 |
| 2WO2 | X-ray | 2.45 Å | A=30-202 |
| 3GXU | X-ray | 2.5 Å | A=29-203 |
| 9CY8 | X-ray | 2.5 Å | A=29-209 |
| 3CKH | X-ray | 2.8 Å | A/B=29-209 |
| 4M4R | X-ray | 3.13 Å | A/C/E/G=27-543 |
| 4BK4 | X-ray | 3.65 Å | A/B=20-547 |
| 4BK5 | X-ray | 4.0 Å | A=20-547 |
| 4BKF | X-ray | 4.65 Å | A/B=20-547 |
| 4BKA | X-ray | 5.3 Å | A=20-547 |
| 2LW8 | NMR | A=29-209 |
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