Synaptojanin-2-binding protein (SYNJ2BP) is a 145-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P57105.
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The mean pLDDT of this model is 78.8 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 56% |
| 70 to 90 | Confident: backbone generally right | 8% |
| 50 to 70 | Low: treat with caution | 22% |
| Below 50 | Very low: often disordered regions | 14% |
What pLDDT means and how to read it
Regulates endocytosis of activin type 2 receptor kinases through the Ral/RALBP1-dependent pathway and may be involved in suppression of activin-induced signal transduction
Binds (via the PDZ domain) to isoform 2A of SYNJ2 (via the unique motif in the C-terminus) (By similarity). Interacts (via C-terminus) with RALBP1. Interacts (via PDZ domain) with ACVR2A (via C-terminus) and ACVR2B (via C-terminus). Forms a ternary complex with ACVR2A and RALBP1 (By similarity). Interacts with MAPK12 (By similarity). Interacts with DLL1; enhances DLL1 protein stability, and…
Mitochondrion outer membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 2JIK | X-ray | 1.35 Å | A/B=5-101 |
| 2JIN | X-ray | 1.5 Å | A=4-99 |
| 7P73 | X-ray | 1.85 Å | A=6-103 |
| 7P74 | X-ray | 1.9 Å | A=6-103 |
| 8AEL | X-ray | 2.2 Å | A=7-103 |
| 7PC9 | X-ray | 2.4 Å | A/B=6-103 |
| 7R2M | X-ray | 2.4 Å | A/D=6-103 |
| 7R2T | X-ray | 2.5 Å | A=6-103 |
| 2ENO | NMR | A=1-107 |
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