Taste receptor type 2 member 46 (TAS2R46) is a 309-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P59540.
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The mean pLDDT of this model is 86.1 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 44% |
| 70 to 90 | Confident: backbone generally right | 47% |
| 50 to 70 | Low: treat with caution | 9% |
| Below 50 | Very low: often disordered regions | 0% |
What pLDDT means and how to read it
Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity). In airway epithelial cells, binding of bitter compounds increases the intracellular calcium ion concentration and stimulates ciliary beat frequency (By similarity)
Membrane, Cell projection, cilium membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 9W0R | EM | 2.7 Å | R=1-304 |
| 9W0U | EM | 2.9 Å | R=1-304 |
| 7XP4 | EM | 3.01 Å | R=2-309 |
| 7XP6 | EM | 3.01 Å | R=2-309 |
| 7XP5 | EM | 3.08 Å | R=2-309 |
| 9W0W | EM | 3.2 Å | R=1-304 |
| 9W0S | EM | 3.3 Å | R=1-304 |
| 9W0T | EM | 3.3 Å | R=1-304 |
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