Nucleoprotein (N) is a 422-residue protein from Severe acute respiratory syndrome coronavirus. This is its AlphaFold structure prediction, created 3 Jul 2025. UniProt accession: P59595.
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The mean pLDDT of this model is 66.7 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 31% |
| 70 to 90 | Confident: backbone generally right | 25% |
| 50 to 70 | Low: treat with caution | 8% |
| Below 50 | Very low: often disordered regions | 36% |
What pLDDT means and how to read it
Packages the positive strand viral genome RNA into a helical ribonucleocapsid (RNP) and plays a fundamental role during virion assembly through its interactions with the viral genome and membrane protein M. Plays an important role in enhancing the efficiency of subgenomic viral RNA transcription as well as viral replication (PubMed:17210170). May modulate transforming growth factor-beta signaling by binding host SMAD3 (PubMed:18055455)
Homooligomer. Both monomeric and oligomeric forms interact with RNA. Interacts with protein M (PubMed:15351485). Interacts with protein E (PubMed:24766657). May bind to host HNRNPA1 (Probable). Interacts with NSP3; this interaction serves to tether the genome to the newly translated replicase-transcriptase complex at a very early stage of infection (By similarity). May interact with host SMAD3…
Virion, Host endoplasmic reticulum-Golgi intermediate compartment, Host Golgi apparatus, Host cytoplasm, host perinuclear region, Host nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 2OFZ | X-ray | 1.17 Å | A=49-174 |
| 1X7Q | X-ray | 1.45 Å | C=362-370 |
| 2GIB | X-ray | 1.75 Å | A/B=270-370 |
| 2OG3 | X-ray | 1.85 Å | A=49-174 |
| 7LG0 | X-ray | 2.3 Å | C=106-114 |
| 6IEX | X-ray | 2.31 Å | C=216-225 |
| 3I6L | X-ray | 2.4 Å | F=346-354 |
| 2CJR | X-ray | 2.5 Å | A/B/C/D/E/F/G/H=248-365 |
| 1SSK | NMR | A=44-181 | |
| 2JW8 | NMR | A/B=248-365 |
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