Protein transport protein Sec61 subunit gamma (SEC61G) is a 68-residue protein from Canis lupus familiaris. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P60058.
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The mean pLDDT of this model is 91.8 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 81% |
| 70 to 90 | Confident: backbone generally right | 16% |
| 50 to 70 | Low: treat with caution | 3% |
| Below 50 | Very low: often disordered regions | 0% |
What pLDDT means and how to read it
Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across the endoplasmic reticulum (ER) (PubMed:8107851). Forms a ribosome receptor and a gated pore in the ER membrane, both functions required for cotranslational translocation of nascent polypeptides (PubMed:8107851). The SEC61 channel is also involved in ER membrane insertion of transmembrane proteins: it mediates membrane insertion of the first few transmembrane segments of proteins, while insertion of subsequent transmembrane regions of multi-pass membrane proteins is mediated by the multi-pass translocon (MPT) complex (PubMed:36261528). The SEC61 channel…
The SEC61 channel-forming translocon complex consists of channel-forming core components SEC61A1, SEC61B and SEC61G and different auxiliary components such as SEC62 and SEC63 (PubMed:36261528, PubMed:8107851). The SEC61 channel associates with the multi-pass translocon (MPT) complex (PubMed:36261528)
Endoplasmic reticulum membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6Z3T | EM | 2.69 Å | B=1-68 |
| 8RJB | EM | 2.69 Å | 3=1-68 |
| 8RJD | EM | 2.79 Å | 3=1-68 |
| 8RJC | EM | 2.9 Å | 3=1-68 |
| 8BTK | EM | 3.5 Å | SY=1-68 |
| 3JC2 | EM | 3.6 Å | 2=7-68 |
| 7TM3 | EM | 3.88 Å | 3=1-68 |
| 7TUT | EM | 3.88 Å | 3=1-68 |
| 6R7Q | EM | 3.9 Å | YY=7-68 |
| 6FTI | EM | 4.2 Å | y=7-68 |
| 6FTJ | EM | 4.7 Å | y=7-68 |
| 2WWB | EM | 6.48 Å | B=1-68 |
| 4CG7 | EM | 6.9 Å | B=1-68 |
| 4CG5 | EM | 7.4 Å | B=1-68 |
| 4CG6 | EM | 7.8 Å | B=1-68 |
| 5A6U | EM | 9.0 Å | G=7-68 |
| 6FTG | EM | 9.1 Å | y=7-68 |
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