6FTG: UL2

Subtomogram average of OST-containing ribosome-translocon complexes from canine rough microsomal membranes. Determined by electron microscopy at 9.1 Å resolution. Released 21 Mar 2018.

Method
Electron microscopy
Resolution
9.1 Å
Organisms
Oryctolagus cuniculus, Canis lupus familiaris
Chains
58
Atoms
152,114
Mol. weight
2264.98 kDa
Ligands
MG, ZN, 9UB
Released
21 Mar 2018

Explore 6FTG in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

6FTG contains 388 α-helices and 323 β-strands across 55 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain 1: 5 helices, 0 β-strands

ElementResiduesLengthSheet
α-helix439-45820
α-helix468-50336
α-helix510-53627
α-helix544-57229
α-helix583-60523
Chain 2: 2 helices, 0 β-strands
ElementResiduesLengthSheet
α-helix18-4124
α-helix53-7523
Chain 3: 5 helices, 2 β-strands
ElementResiduesLengthSheet
α-helix31-4616
α-helix49-524
β-strand5917
β-strand7117
α-helix84-10320
α-helix104-1085
α-helix118-14528
Chain 4: 1 helix, 0 β-strands
ElementResiduesLengthSheet
α-helix4-3128
Chain 5: 28 helices, 7 β-strands
ElementResiduesLengthSheet
α-helix14-3320
α-helix36-405
α-helix50-6213
α-helix91-10515
α-helix113-1164
α-helix119-13618
α-helix141-15212
α-helix155-1595
α-helix172-18716
α-helix192-20817
α-helix212-22817
α-helix234-25219
α-helix265-28521
α-helix295-31622
α-helix365-3695
α-helix371-38010
α-helix386-39914
α-helix405-4084
α-helix410-42920
α-helix457-48125
α-helix504-51411
α-helix526-5283
α-helix529-5357
α-helix550-5567
α-helix563-57210
β-strand577-578220
β-strand581121
α-helix596-6016
β-strand618-619222
β-strand623-624222
α-helix632-6365
α-helix639-6424
β-strand678-680320
β-strand689121
β-strand692-694320
Chain 6: 6 helices, 0 β-strands
ElementResiduesLengthSheet
α-helix6-1813
α-helix22-4423
α-helix56-7722
α-helix91-999
α-helix101-1044
α-helix106-1094
Chain 7: 1 helix, 0 β-strands
ElementResiduesLengthSheet
α-helix416-43722
Chain 8: 3 helices, 0 β-strands
ElementResiduesLengthSheet
α-helix539-56123
α-helix578-59720
α-helix601-62727

47 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
uL2Aprotein244Oryctolagus cuniculusG1TT27 (AlphaFold model)
uL3Bprotein394Oryctolagus cuniculusG1TL06 (AlphaFold model)
Ribosomal protein L4Cprotein362Oryctolagus cuniculusG1SVW5 (AlphaFold model)
60S ribosomal protein L5Dprotein292Oryctolagus cuniculusP19949 (AlphaFold model)
60S ribosomal protein L6Eprotein248Oryctolagus cuniculusG1TG04
uL30Fprotein225Oryctolagus cuniculusG1SV32
eL8Gprotein241Oryctolagus cuniculusG1STW0
uL6Hprotein190Oryctolagus cuniculusG1SWI6
Ribosomal protein L10 (Predicted)Iprotein213Oryctolagus cuniculusB7NZQ2
Ribosomal protein L11Jprotein169Oryctolagus cuniculusG1TUB8
eL13Lprotein210Oryctolagus cuniculus
Ribosomal protein L14Mprotein138Oryctolagus cuniculusG1SZ12

46 more molecules are not listed.

Sequence of entity 1 (A), FASTA
>6FTG_1 uL2 (chains A)
GRVIRGQRKGAGSVFRAHVKHRKGAARLRAVDFAERHGYIKGIVKDIIHDPGRGAPLAKV
VFRDPYRFKKRTELFIAAEGIHTGQFVYCGKKAQLNIGNVLPVGTMPEGTIVCCLEEKPG
DRGKLARASGNYATVISHNPETKKTRVKLPSGSKKVISSANRAVVGVVAGGGRIDKPILK
AGRAYHKYKAKRNCWPRVRGVAMNPVEHPFGGGNHQHIGKPSTIRRDAPAGRKVGLIAAR
RTGR
Sequence of entity 2 (B), FASTA
>6FTG_2 uL3 (chains B)
SHRKFSAPRHGSLGFLPRKRSSRHRGKVKSFPKDDPSKPVHLTAFLGYKAGMTHIVREVD
RPGSKVNKKEVVEAVTIVETPPMVVVGIVGYVETPRGLRTFKTVFAEHISDECKRRFYKN
WHKSKKKAFTKYCKKWQDDAGKRQLDKDFSSMKKYCQVIRVLAHTQMRLLPLRQKKAHLM
EIQVNGGTVAEKLDWARERLEQQVPVSQVFGQDEMIDVIGVTKGKGYKGVTSRWHTKKLP
RKTHRGLRKVACIGAWHPARVAFSVARAGQKGYHHRTEINKKIYKIGQGYLIKDGKLIKN
NASTDYDLSDKSINPLGGFVHYGEVTNDFVMLKGCVVGTKKRVLTLRKSLLVQTKRRALE
KIDLKFIDTTSKFGHGRFQTVEEKKAFMGPLKKD
Sequence of entity 3 (C), FASTA
>6FTG_3 Ribosomal protein L4 (chains C)
ACARPLISVYSEKGESSGKNVTLPAVFKAPIRPDIVNFVHTNLRKNNRQPYAVSELAGHQ
TSAESWGTGRAVARIPRVRGGGTHRSGQGAFGNMCRGGRMFAPTKTWRRWHRRVNTTQKR
YAICSALAASALPALVMSKGHRIEEVPELPLVVEDKVEGYKKTKEAVLLLKKLKAWNDIK
KVYASQRMRAGKGKMRNRRRIQRRGPCVIYNEDNGIVKAFRNIPGITLLNVTKLNILKLA
PGGHVGRFCIWTESAFRKLDDLYGTWRKAASLKSNYNLPMHKMLNTDLSRILKSPEIQRA
LRAPRKKIHRRVLKKNPLKNLRIMLKLNPYAKTMRRNTILRQARNHKLRVERAAAALAAK
KS
Sequence of entity 4 (D), FASTA
>6FTG_4 60S ribosomal protein L5 (chains D)
FVKVVKNKAYFKRYQVKFRRRREGKTDYYARKRLVIQDKNKYNTPKYRMIVRVTNRDIIC
QIAYARIEGDMIVCAAYAHELPKYGVKVGLTNYAAAYCTGLLLARRLLNRFGMDKIYEGQ
VEVTGDEYNVESIDGQPGAFTCYLDAGLARTTTGNKVFGALKGAVDGGLSIPHSTKRFPG
YDSESKEFNAEVHRKHIMGQNVADYMRYLMEEDEDAYKKQFSQYIKNNVTPDMMEEMYKK
AHAAIRENPVYEKKPKREVKKKRWNRPKMSLAQKKDRVAQKKASFLRAQERA
Sequence of entity 5 (E), FASTA
>6FTG_5 60S ribosomal protein L6 (chains E)
PHCSRNPVLVRGIGRYSRSAMYSRKALYKRKYAAPKSRIERKKKREKVLATVTKPVGGDK
NGGTRVVKLRKMPRYYPTEDVPRKLLSHGRKPFSQHVRKLRASITPGTILIILTGRHRGK
RVVFLKQLSSGLLLVTGPLSLNRVPLRRTHQKFVIATSTKIDISGVKIPKHLTDAYFKKK
QLRKPRHQEGEIFDTEKEKYEITEQRKVDQKAVDSQILPKIKAVPQLQGYLRSVFALTNG
VYPHKLVF
Sequence of entity 6 (F), FASTA
>6FTG_6 uL30 (chains F)
NFAELKIKRLRKKFAQKMLRKARRKLIYEKAKHYHKEYRQMYRTEIRMARMARKAGNFYV
PAEPKLAFVIRIRGINGVSPKVRKVLQLLRLRQIFNGTFVKLNKASINMLRIVEPYIAWG
YPNLKSVNELIYKRGYGKINKKRIALTDNALIARSLGKYGIICMEDLIHEIYTVGKRFKE
ANNFLWPFKLSSPRGGMKKKTTHFVEGEDAGNREDQINRLIRRMN
Sequence of entity 7 (G), FASTA
>6FTG_7 eL8 (chains G)
KVVNPLFEKRPKNFGIGQDIQPKRDLTRFVKWPRYIRLQRQRAILYKRLKVPPAINQFTQ
VLDRQTATQLLKLAHKYRPETKQEKKQRLLARAEKKAAGKGDVPTKRPPVLRAGVNTVTT
LVENKKAQLVVIAHDVDPIELVVFLPALCRKMGVPYCILKGKARLGRLVHRKTCTTVAFT
QVNSEDKGALAKLVEAIRTNYNDRYDEIRRHWGGNVLGPKSVARIAKLEKAKAKELATKL
G
Sequence of entity 8 (H), FASTA
>6FTG_8 uL6 (chains H)
MKTILSNQTVDIPENVDISLKGRTVIVKGPRGTLRRDFNHINVELSLLGKKKKRLRVDKW
WGNRKELATVRTICSHVQNMIKGVTLGFRYKMRSVYAHFPINVVIQENGSLVEIRNFLGE
KYIRRVRMRPGVACSVSQAQKDELVLEGNDIELVSNSAALIQQATTVKNKDIRKFLDGIY
VSEKGTVQQA
Sequence of entity 9 (I), FASTA
>6FTG_9 Ribosomal protein L10 (Predicted) (chains I)
GRRPARCYRYCKNKPYPKSRFCRGVPDAKIRIFDLGRKKAKVDEFPLCGHMVSDEYEQLS
SEALEAARICANKYMVKSCGKDGFHIRVRLHPFHVIRINKMLSCAGADRLQTGMRGAFGK
PQGTVARVHIGQVIMSIRTKLQNKEHVVEALRRAKFKFPGRQKIHISKKWGFTKFNADEF
EDMVAEKRLIPDGCGVKYIPNRGPLDKWRALHS
Sequence of entity 10 (J), FASTA
>6FTG_10 Ribosomal protein L11 (chains J)
ENPMRELRIRKLCLNICVGESGDRLTRAAKVLEQLTGQTPVFSKARYTVRSFGIRRNEKI
AVHCTVRGAKAEEILEKGLKVREYELRKNNFSDTGNFGFGIQEHIDLGIKYDPSIGIYGL
DFYVVLGRPGFSIADKKRRTGCIGAKHRISKEEAMRWFQQKYDGIILPG
Sequence of entity 11 (L), FASTA
>6FTG_11 eL13 (chains L)
APSRNGMILKPHFHKDWQRRVATWFNQPARKIRRRKARQARARRIAPRPASGPLRPIVRC
PTVRYHTKVRAGRGFSLEELRVAGIHKKVARTIGISVDPRRRNKSTESLQANVQRLKEYR
SKLVLFPRKPSAPKKGDSSAEELKLATQLTGPVMPIRNVFKKEKARVITEEEKNFKAFAS
LRMARANARLFGIRAKRAKEAAEQDVEKKK
Sequence of entity 12 (M), FASTA
>6FTG_12 Ribosomal protein L14 (chains M)
VFRRFVEVGRVAYVSFGPHAGKLVAIVDVIDQNRALVDGPCTRVRRQAMPFKCMQLTDFI
LKFPHSARQKYVRKAWEKADINTKWAATRWAKKIEARERKAKMTDFDRYKVMKAKKMRNR
IIKNEVKKLQRAALLKAS

Ligands and cofactors

IDNameFormulaCopies
MGMagnesium ionMg159
ZNZinc ionZn5
9UB[(2~{S},3~{R},4~{R},5~{S},6~{R})-3-acetamido-6-(hydroxymethyl)-4,5-bis(oxidanyl…C29 H51 N O11 P21

Primary citation

Structural basis for coupling protein transport and N-glycosylation at the mammalian endoplasmic reticulum. Braunger, K., Pfeffer, S., Shrimal, S. et al. Science (2018) 360:215-219. DOI 10.1126/science.aar7899 · PubMed

Other PDB entries of the same protein (UniProt G1TT27 (AlphaFold model), which also has an AlphaFold model), best resolution first:

Browse structure collections

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