Ubiquitin-conjugating enzyme E2 K (UBE2K) is a 200-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P61086.
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The mean pLDDT of this model is 96.7 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 96% |
| 70 to 90 | Confident: backbone generally right | 5% |
| 50 to 70 | Low: treat with caution | 0% |
| Below 50 | Very low: often disordered regions | 0% |
What pLDDT means and how to read it
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro, in the presence or in the absence of BRCA1-BARD1 E3 ubiquitin-protein ligase complex, catalyzes the synthesis of 'Lys-48'-linked polyubiquitin chains. Does not transfer ubiquitin directly to but elongates monoubiquitinated substrate protein. Mediates the selective degradation of short-lived and abnormal proteins, such as the endoplasmic reticulum-associated degradation (ERAD) of misfolded lumenal proteins. Ubiquitinates huntingtin. May mediate foam cell formation by the suppression of apoptosis of lipid-bearing macrophages through ubiquitination and subsequence degradation of p53/TP53.…
Interacts with RNF138/NARF. Interacts with BRCA1
Cytoplasm
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 3K9O | X-ray | 1.8 Å | A=1-200 |
| 3E46 | X-ray | 1.86 Å | A=1-200 |
| 5DFL | X-ray | 2.1 Å | A=1-200 |
| 6JB7 | X-ray | 2.1 Å | A=1-200 |
| 3F92 | X-ray | 2.23 Å | A=1-200 |
| 7MYH | X-ray | 2.39 Å | A=2-200 |
| 1YLA | X-ray | 2.4 Å | A/B=1-200 |
| 7OJX | X-ray | 2.4 Å | B=1-200 |
| 6IF1 | X-ray | 2.47 Å | A/B=1-199 |
| 2O25 | X-ray | 2.6 Å | A/B=1-200 |
| 6JB6 | X-ray | 2.7 Å | A=1-200 |
| 3K9P | X-ray | 2.8 Å | A=1-200 |
| 7MYF | X-ray | 3.0 Å | A=2-200 |
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