Protein transport protein Sec61 subunit alpha isoform 1 (SEC61A1) is a 476-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P61619.
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The mean pLDDT of this model is 72.9 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 0% |
| 70 to 90 | Confident: backbone generally right | 64% |
| 50 to 70 | Low: treat with caution | 33% |
| Below 50 | Very low: often disordered regions | 3% |
What pLDDT means and how to read it
Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across the endoplasmic reticulum (ER) (PubMed:12475939, PubMed:22375059, PubMed:28782633, PubMed:29719251, PubMed:32814900). Forms a ribosome receptor and a gated pore in the ER membrane, both functions required for cotranslational translocation of nascent polypeptides (PubMed:22375059, PubMed:28782633, PubMed:29719251). May cooperate with auxiliary protein SEC62, SEC63 and HSPA5/BiP to enable post-translational transport of small presecretory proteins (PubMed:22375059, PubMed:29719251). The SEC61 channel is also involved in ER membrane insertion of…
The SEC61 channel-forming translocon complex consists of channel-forming core components SEC61A1, SEC61B and SEC61G and different auxiliary components such as SEC62 and SEC63 (PubMed:36697828). The SEC61 channel associates with the multi-pass translocon (MPT) complex (PubMed:32820719, PubMed:36261522)
Endoplasmic reticulum membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 8DNZ | EM | 2.57 Å | A=1-476 |
| 8DNY | EM | 2.85 Å | A=1-476 |
| 8DO0 | EM | 2.86 Å | A=1-476 |
| 8DO2 | EM | 2.95 Å | A=1-476 |
| 8DNX | EM | 2.98 Å | A=1-476 |
| 8DO1 | EM | 3.01 Å | A=1-476 |
| 8DNV | EM | 3.03 Å | A=1-476 |
| 9D6L | EM | 3.1 Å | A=1-476 |
| 9N9J | EM | 3.2 Å | D=1-476 |
| 8DO3 | EM | 3.22 Å | A=1-476 |
| 8DNW | EM | 3.4 Å | A=1-476 |
| 6W6L | EM | 3.84 Å | 1=1-476 |
| 9YGY | EM | 4.1 Å | D=1-476 |
| 8B6L | EM | 7.6 Å | A=1-476 |
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