cAMP-dependent protein kinase inhibitor alpha (PKIA) is a 76-residue protein from Oryctolagus cuniculus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P61926.
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The mean pLDDT of this model is 64.7 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 3% |
| 70 to 90 | Confident: backbone generally right | 32% |
| 50 to 70 | Low: treat with caution | 51% |
| Below 50 | Very low: often disordered regions | 14% |
What pLDDT means and how to read it
Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 4XW4 | X-ray | 1.82 Å | B=6-25 |
| 2GFC | X-ray | 1.87 Å | I=6-25 |
| 4XW6 | X-ray | 1.9 Å | B=6-25 |
| 4XW5 | X-ray | 1.95 Å | B=6-25 |
| 1CDK | X-ray | 2.0 Å | I/J=6-25 |
| 3DNE | X-ray | 2.0 Å | I=6-25 |
| 1SVG | X-ray | 2.02 Å | B=6-25 |
| 1SMH | X-ray | 2.04 Å | B=6-25 |
| 2GNH | X-ray | 2.05 Å | I=6-25 |
| 4YXS | X-ray | 2.11 Å | I=6-25 |
| 1FMO | X-ray | 2.2 Å | I=6-25 |
| 1JBP | X-ray | 2.2 Å | S=6-25 |
| 1Q8W | X-ray | 2.2 Å | B=6-25 |
| 2ERZ | X-ray | 2.2 Å | I=6-25 |
| 3DND | X-ray | 2.26 Å | I=6-25 |
| 1STC | X-ray | 2.3 Å | I=6-25 |
| 5UZK | X-ray | 2.3 Å | I=6-23 |
| 1SVE | X-ray | 2.49 Å | B=6-25 |
| 2GNL | X-ray | 2.6 Å | I=6-25 |
| 1CTP | X-ray | 2.9 Å | I=6-25 |
Showing 20 of 21 experimental structures (best resolution first).
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