Neuronal calcium sensor 1 (Ncs1) is a 190-residue protein from Rattus norvegicus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P62168.
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The mean pLDDT of this model is 88.6 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 66% |
| 70 to 90 | Confident: backbone generally right | 28% |
| 50 to 70 | Low: treat with caution | 5% |
| Below 50 | Very low: often disordered regions | 2% |
What pLDDT means and how to read it
Neuronal calcium sensor, regulator of G protein-coupled receptor phosphorylation in a calcium dependent manner. Directly regulates GRK1 (RHOK), but not GRK2 to GRK5. Can substitute for calmodulin. Stimulates PI4KB kinase activity. Involved in long-term synaptic plasticity through its interaction with PICK1. May also play a role in neuron differentiation through inhibition of the activity of N-type voltage-gated calcium channel
Monomer (PubMed:25979333). Interacts with KCND2 (By similarity). Interacts in a calcium-independent manner with PI4KB, but only if myristoylated (PubMed:11526106). This binding competes with CALN2/CABP7 binding to PI4KB (PubMed:11526106). Interacts in a calcium-dependent manner with PICK1 (via AH domain) (PubMed:19109914). Interacts with ARF1, ARF3, ARF5 and ARF6 (By similarity). Interacts with…
Golgi apparatus, Postsynaptic density, Cytoplasm, perinuclear region, Cytoplasm, Cell membrane, Membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 5AEQ | X-ray | 1.95 Å | A/B=1-190 |
| 5AER | X-ray | 2.19 Å | A=1-190 |
| 5AFP | X-ray | 2.3 Å | A/B=1-190 |
| 4OV2 | X-ray | 2.6 Å | A/B/C/D=1-177 |
| 4YRU | X-ray | 2.8 Å | A/B/C/D=1-177 |
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