Beta-lactamase TEM (bla) is a 286-residue protein from Escherichia coli. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P62593.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 94.9 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 91% |
| 70 to 90 | Confident: backbone generally right | 0% |
| 50 to 70 | Low: treat with caution | 7% |
| Below 50 | Very low: often disordered regions | 1% |
What pLDDT means and how to read it
TEM-type are the most prevalent beta-lactamases in enterobacteria; they hydrolyze the beta-lactam bond in susceptible beta-lactam antibiotics, thus conferring resistance to penicillins and cephalosporins. TEM-3 and TEM-4 are capable of hydrolyzing cefotaxime and ceftazidime. TEM-5 is capable of hydrolyzing ceftazidime. TEM-6 is capable of hydrolyzing ceftazidime and aztreonam. TEM-8/CAZ-2, TEM-16/CAZ-7 and TEM-24/CAZ-6 are markedly active against ceftazidime. IRT-4 shows resistance to beta-lactamase inhibitors
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 1M40 | X-ray | 0.85 Å | A=24-286 |
| 4ID4 | X-ray | 1.05 Å | A=24-147, A=189-286 |
| 4R4S | X-ray | 1.1 Å | A=24-149, A=189-286 |
| 4QY6 | X-ray | 1.15 Å | A=24-147, A=189-286 |
| 1NYM | X-ray | 1.2 Å | A=24-286 |
| 4R4R | X-ray | 1.2 Å | A=24-147, A=189-286 |
| 4RX3 | X-ray | 1.39 Å | A=24-286 |
| 1YT4 | X-ray | 1.4 Å | A=24-286 |
| 5HW5 | X-ray | 1.41 Å | A/B/C/D=24-286 |
| 4RVA | X-ray | 1.44 Å | A=24-286 |
| 6AYK | X-ray | 1.44 Å | A/B/C/D=24-286 |
| 1PZP | X-ray | 1.45 Å | A=24-286 |
| 8DDZ | X-ray | 1.45 Å | A/B/C/D=24-286 |
| 4QY5 | X-ray | 1.5 Å | A=24-147, A=189-286 |
| 5KPU | X-ray | 1.5 Å | A/B/C/D=24-286 |
| 1LI9 | X-ray | 1.52 Å | A=24-286 |
| 4ZJ1 | X-ray | 1.54 Å | A=1-286 |
| 1ZG4 | X-ray | 1.55 Å | A=1-286 |
| 8DE1 | X-ray | 1.56 Å | A/B/C/D=24-286 |
| 1NXY | X-ray | 1.6 Å | A=24-286 |
Showing 20 of 78 experimental structures (best resolution first).
MolViewer loads the AlphaFold model straight from AlphaFold DB into your browser. Show it as a cartoon, color by pLDDT, measure distances and angles, and load a PDB structure next to it to compare.