Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 (GNB1) is a 340-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P62873.
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The mean pLDDT of this model is 97.1 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 97% |
| 70 to 90 | Confident: backbone generally right | 3% |
| 50 to 70 | Low: treat with caution | 0% |
| Below 50 | Very low: often disordered regions | 0% |
What pLDDT means and how to read it
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems (PubMed:29925951, PubMed:33762731, PubMed:34239069, PubMed:35610220, PubMed:35714614, PubMed:35835867, PubMed:36087581, PubMed:36989299, PubMed:37327704, PubMed:37935376, PubMed:37935377, PubMed:37963465, PubMed:37991948, PubMed:38168118, PubMed:38552625, PubMed:39103320). The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction (PubMed:29925951, PubMed:33762731, PubMed:34239069, PubMed:35610220, PubMed:35714614, PubMed:35835867, PubMed:36087581, PubMed:36989299, PubMed:37327704,…
G proteins are composed of 3 units, alpha, beta and gamma (PubMed:29925951, PubMed:33762731, PubMed:34239069, PubMed:35610220, PubMed:35714614, PubMed:35835867, PubMed:36087581, PubMed:36989299, PubMed:37327704, PubMed:37935376, PubMed:37935377, PubMed:37963465, PubMed:38168118, PubMed:38552625, PubMed:39103320). The heterodimer formed by GNB1 and GNG2 interacts with ARHGEF5 (PubMed:19713215).…
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 8QEH | X-ray | 1.43 Å | B=2-340 |
| 8QEG | X-ray | 1.7 Å | B=2-340 |
| 8F0K | EM | 1.9 Å | B=2-340 |
| 9YDQ | EM | 1.94 Å | B=2-340 |
| 9YDP | EM | 1.95 Å | B=2-340 |
| 6CRK | X-ray | 2.0 Å | B=2-340 |
| 8F0J | EM | 2.0 Å | B=2-340 |
| 8F2B | EM | 2.0 Å | B=2-340 |
| 9XXT | EM | 2.0 Å | B=2-340 |
| 6X18 | EM | 2.1 Å | B=2-340 |
| 6X19 | EM | 2.1 Å | B=2-340 |
| 9P7Z | EM | 2.1 Å | B=2-340 |
| 7RTB | EM | 2.14 Å | B=2-340 |
| 9YDR | EM | 2.14 Å | B=2-340 |
| 5UKL | X-ray | 2.15 Å | B=2-340 |
| 7TYF | EM | 2.2 Å | B=2-340 |
| 8F2A | EM | 2.2 Å | B=2-340 |
| 9BP3 | EM | 2.2 Å | B=2-340 |
| 9MZE | EM | 2.2 Å | B=2-340 |
| 9N05 | EM | 2.2 Å | B=2-340 |
Showing 20 of 1204 experimental structures (best resolution first).
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