Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 (Gnb1) is a 340-residue protein from Mus musculus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P62874.
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The mean pLDDT of this model is 97.1 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 97% |
| 70 to 90 | Confident: backbone generally right | 3% |
| 50 to 70 | Low: treat with caution | 0% |
| Below 50 | Very low: often disordered regions | 0% |
What pLDDT means and how to read it
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems (By similarity). The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction (By similarity). Involved in bitter and sweet taste transduction as well as in umami (monosodium glutamate, monopotassium glutamate, and inosine monophosphate) taste transduction (By similarity)
G proteins are composed of 3 units, alpha, beta and gamma (By similarity). The heterodimer formed by GNB1 and GNG2 interacts with ARHGEF5 (By similarity). The heterodimer formed by GNB1 and GNG2 interacts with GRK2 (By similarity). The heterodimer formed by GNB1 and GNG2 interacts with the ghrelin receptor GHSR (By similarity). Forms a complex with GNAO1 and GNG3 (By similarity). Forms a complex…
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6RMV | X-ray | 1.94 Å | A=1-340 |
| 8IHB | EM | 2.85 Å | B=2-340 |
| 22EM | EM | 2.86 Å | C=6-340 |
| 6K41 | EM | 2.9 Å | B=2-340 |
| 7Y15 | EM | 2.9 Å | B=2-340 |
| 8IHF | EM | 2.97 Å | B=2-340 |
| 8IHH | EM | 3.06 Å | B=2-340 |
| 8IHJ | EM | 3.07 Å | B=2-340 |
| 7Y12 | EM | 3.1 Å | B=2-340 |
| 8IHI | EM | 3.11 Å | B=2-340 |
| 6K42 | EM | 4.1 Å | B=2-340 |
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