cAMP-dependent protein kinase inhibitor alpha (Pkia) is a 76-residue protein from Mus musculus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P63248.
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The mean pLDDT of this model is 63.8 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 5% |
| 70 to 90 | Confident: backbone generally right | 30% |
| 50 to 70 | Low: treat with caution | 43% |
| Below 50 | Very low: often disordered regions | 21% |
What pLDDT means and how to read it
Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 4DFX | X-ray | 1.35 Å | I=6-25 |
| 7PIH | X-ray | 1.37 Å | B=6-25 |
| 6YNC | X-ray | 1.4 Å | B=12-30 |
| 7PIF | X-ray | 1.4 Å | B=6-25 |
| 6YQI | X-ray | 1.42 Å | B=12-30 |
| 7PIE | X-ray | 1.43 Å | B=6-25 |
| 6YNA | X-ray | 1.47 Å | B=12-30 |
| 7PID | X-ray | 1.5 Å | B=6-25 |
| 6YNT | X-ray | 1.52 Å | B=6-25 |
| 7BAQ | X-ray | 1.54 Å | B=6-23 |
| 4HPU | X-ray | 1.55 Å | I=6-25 |
| 7PIG | X-ray | 1.55 Å | B=6-25 |
| 6Y89 | X-ray | 1.56 Å | B=6-25 |
| 6YQJ | X-ray | 1.58 Å | B=12-30 |
| 3FJQ | X-ray | 1.6 Å | I=6-25 |
| 6YQK | X-ray | 1.67 Å | B=12-30 |
| 7AXW | X-ray | 1.69 Å | B=6-25 |
| 3QAL | X-ray | 1.7 Å | I=6-23 |
| 6Y05 | X-ray | 1.7 Å | B=6-25 |
| 6Y0B | X-ray | 1.71 Å | B=6-25 |
Showing 20 of 50 experimental structures (best resolution first).
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