Intermembrane phospholipid transport system binding protein MlaB (mlaB) is a 97-residue protein from Escherichia coli (strain K12). This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P64602.
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The mean pLDDT of this model is 92.6 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 89% |
| 70 to 90 | Confident: backbone generally right | 9% |
| 50 to 70 | Low: treat with caution | 2% |
| Below 50 | Very low: often disordered regions | 0% |
What pLDDT means and how to read it
Part of the ABC transporter complex MlaFEDB, which is involved in a phospholipid transport pathway that maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane (PubMed:19383799, PubMed:27529189). MlaB plays critical roles in both the assembly and activity of the complex. May act by modulating MlaF structure and stability (PubMed:27529189)
The complex is composed of two ATP-binding proteins (MlaF), two transmembrane proteins (MlaE), two cytoplasmic solute-binding proteins (MlaB) and six periplasmic solute-binding proteins (MlaD)
Cytoplasm
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6XGZ | X-ray | 2.6 Å | B/D/F/H=2-97 |
| 6XGY | X-ray | 2.9 Å | B=2-97 |
| 7CGE | EM | 2.9 Å | C/F=1-97 |
| 6ZY3 | EM | 3.3 Å | B/C=1-97 |
| 6ZY9 | EM | 3.3 Å | B/C=1-97 |
| 7CH6 | EM | 3.4 Å | E/F=1-97 |
| 6ZY2 | EM | 3.6 Å | B/C=1-97 |
| 7CH0 | EM | 3.7 Å | C/F=1-97 |
| 7CH7 | EM | 3.9 Å | E/F=1-97 |
| 6ZY4 | EM | 4.1 Å | B/C=1-97 |
| 7CGN | EM | 4.3 Å | C/F=1-97 |
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