Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (PPP2CA) is a 309-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P67775.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 95.1 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 92% |
| 70 to 90 | Confident: backbone generally right | 2% |
| 50 to 70 | Low: treat with caution | 2% |
| Below 50 | Very low: often disordered regions | 4% |
What pLDDT means and how to read it
Catalytic subunit of protein phosphatase 2A (PP2A), a serine/threonine phosphatase involved in the regulation of a wide variety of enzymes, signal transduction pathways, and cellular events (PubMed:10801873, PubMed:12473674, PubMed:17245430, PubMed:22613722, PubMed:33243860, PubMed:34004147, PubMed:9920888, PubMed:41986709). PP2A is the major phosphatase for microtubule-associated proteins (MAPs) (PubMed:22613722). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase (PubMed:22613722). Cooperates with SGO2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (By…
PP2A consists of a common heterodimeric core enzyme composed of PPP2CA, a 36 kDa catalytic subunit (subunit C), and PPP2R1A, a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits (PubMed:17055435, PubMed:18394995, PubMed:30595372, PubMed:38123684). Proteins that associate with the core dimer include three families of regulatory subunits B…
Cytoplasm, Nucleus, Chromosome, Chromosome, centromere, Cytoplasm, cytoskeleton, spindle pole
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 4NY3 | X-ray | 1.8 Å | C/D=304-309 |
| 4I5L | X-ray | 2.43 Å | C/F=1-309 |
| 8TWE | EM | 2.55 Å | C=1-309 |
| 2IE4 | X-ray | 2.6 Å | C=1-309 |
| 9C6B | EM | 2.6 Å | C=1-309 |
| 8TWI | EM | 2.69 Å | C=1-309 |
| 3FGA | X-ray | 2.7 Å | C=1-309 |
| 3P71 | X-ray | 2.7 Å | C=1-309 |
| 8U1X | EM | 2.7 Å | C=1-309 |
| 9C7T | EM | 2.7 Å | C=1-309 |
| 8TTB | EM | 2.77 Å | C=1-309 |
| 2IE3 | X-ray | 2.8 Å | C=1-309 |
| 3C5W | X-ray | 2.8 Å | C=1-309 |
| 4I5N | X-ray | 2.8 Å | C/F=1-309 |
| 4IYP | X-ray | 2.8 Å | C=6-153 |
| 8SO0 | EM | 2.8 Å | C=1-309 |
| 4LAC | X-ray | 2.82 Å | C=1-309 |
| 3DW8 | X-ray | 2.85 Å | C/F=1-309 |
| 3K7V | X-ray | 2.85 Å | C=1-309 |
| 3K7W | X-ray | 2.96 Å | C=1-309 |
Showing 20 of 50 experimental structures (best resolution first).
MolViewer loads the AlphaFold model straight from AlphaFold DB into your browser. Show it as a cartoon, color by pLDDT, measure distances and angles, and load a PDB structure next to it to compare.