3FGA: PP2A and Sgo interaction

Structural Basis of PP2A and Sgo interaction. Determined by X-ray diffraction at 2.7 Å resolution. Released 22 Sept 2009.

Method
X-ray diffraction
Resolution
2.7 Å
Organisms
Mus musculus, Homo sapiens, Microcystis aeruginosa
Chains
5
Atoms
10,810
Mol. weight
155.27 kDa
Ligands
MN
Released
22 Sept 2009

Explore 3FGA in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

3FGA contains 105 α-helices and 14 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 62 helices, 0 β-strands

ElementResiduesLengthSheet
α-helix11-2111
α-helix25-339
α-helix35-417
α-helix44-463
α-helix47-515
α-helix52-565
α-helix63-7311
α-helix86-894
α-helix90-989
α-helix102-11615
α-helix121-1233
α-helix124-1285
α-helix129-1368
α-helix141-1477
α-helix151-1544
α-helix155-1573
α-helix160-17415
α-helix179-1879
α-helix189-1935
α-helix198-2003
α-helix201-2055
α-helix206-2138
α-helix218-23215
α-helix237-2426
α-helix244-2518
α-helix257-2659
α-helix267-2748
α-helix276-2783
α-helix279-2835
α-helix284-2918
α-helix296-3038
α-helix306-3116
α-helix318-3214
α-helix322-3265
α-helix327-3348
α-helix339-3468
α-helix349-3524
α-helix353-3608
α-helix361-3655
α-helix366-3738
α-helix378-3858
α-helix389-3946
α-helix397-4037
α-helix405-4117
α-helix417-4248
α-helix427-4348
α-helix436-4427
α-helix444-4507
α-helix456-47318
α-helix475-4773
α-helix478-4825
α-helix483-4886
α-helix489-4913
α-helix495-51622
α-helix517-5215
α-helix522-5287
α-helix534-54714
α-helix548-5503
α-helix553-5553
α-helix556-5605
α-helix561-5688
α-helix573-58513
Chain B: 28 helices, 0 β-strands
ElementResiduesLengthSheet
α-helix27-3812
α-helix53-7220
α-helix81-9313
α-helix96-1005
α-helix110-1123
α-helix121-13616
α-helix142-1454
α-helix151-1599
α-helix160-1623
α-helix166-18217
α-helix184-20017
α-helix201-2055
α-helix211-22414
α-helix231-2355
α-helix236-2416
α-helix243-2464
α-helix250-2523
α-helix254-26714
α-helix269-2713
α-helix272-28110
α-helix288-30215
α-helix307-32519
α-helix330-3378
α-helix338-3414
α-helix343-3508
α-helix353-36614
α-helix374-38815
α-helix399-42022
Chain C: 14 helices, 14 β-strands
ElementResiduesLengthSheet
α-helix5-1814
α-helix25-3915
β-strand45-4841
β-strand52-5542
α-helix62-7211
β-strand80-8232
α-helix93-10614
β-strand111-11332
α-helix121-1266
α-helix129-1379
α-helix141-15010
β-strand156-15941
β-strand163-16641
α-helix177-1815
α-helix188-1903
α-helix194-2007
β-strand202-20323
β-strand210-21123
β-strand218-22033
α-helix222-23211
β-strand236-23941
β-strand248-25141
β-strand256-25941
α-helix265-2673
β-strand273-27862
β-strand286-28942
α-helix291-2933
α-helix302-3054
Chain D: 1 helix, 0 β-strands
ElementResiduesLengthSheet
α-helix51-9343

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoformAprotein588Mus musculusQ76MZ3 (AlphaFold model)
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoformBprotein403Homo sapiensQ13362 (AlphaFold model)
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoformCprotein309Homo sapiensP67775 (AlphaFold model)
Shugoshin-like 1Dprotein47Homo sapiensQ5FBB7 (AlphaFold model)
Microcystin-lrEprotein7Microcystis aeruginosa
Sequence of entity 1 (A), FASTA
>3FGA_1 Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (chains A)
AAADGDDSLYPIAVLIDELRNEDVQLRLNSIKKLSTIALALGVERTRSELLPFLTDTIYD
EDEVLLALAEQLGTFTTLVGGPEYVHCLLPPLESLATVEETVVRDKAVESLRAISHEHSP
SDLEAHFVPLVKRLAGGDWFTSRTSACGLFSVCYPRVSSAVKAELRQYFRNLCSDDTPMV
RRAAASKLGEFAKVLELDNVKSEIIPMFSNLASDEQDSVRLLAVEACVNIAQLLPQEDLE
ALVMPTLRQAAEDKSWRVRYMVADKFTELQKAVGPEITKTDLVPAFQNLMKDCEAEVRAA
ASHKVKEFCENLSADCRENVIMTQILPCIKELVSDANQHVKSALASVIMGLSPILGKDNT
IEHLLPLFLAQLKDECPEVRLNIISNLDCVNEVIGIRQLSQSLLPAIVELAEDAKWRVRL
AIIEYMPLLAGQLGVEFFDEKLNSLCMAWLVDHVYAIREAATSNLKKLVEKFGKEWAHAT
IIPKVLAMSGDPNYLHRMTTLFCINVLSEVCGQDITTKHMLPTVLRMAGDPVANVRFNVA
KSLQKIGPILDNSTLQSEVKPILEKLTQDQDVDVKYFAQEALTVLSLA
Sequence of entity 2 (B), FASTA
>3FGA_2 Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform (chains B)
PPADQEKLFIQKLRQCCVLFDFVSDPLSDLKWKEVKRAALSEMVEYITHNRNVITEPIYP
EVVHMFAVNMFRTLPPSSNPTGAEFDPEEDEPTLEAAWPHLQLVYEFFLRFLESPDFQPN
IAKKYIDQKFVLQLLELFDSEDPRERDFLKTTLHRIYGKFLGLRAYIRKQINNIFYRFIY
ETEHHNGIAELLEILGSIINGFALPLKEEHKIFLLKVLLPLHKVKSLSVYHPQLAYCVVQ
FLEKDSTLTEPVVMALLKYWPKTHSPKEVMFLNELEEILDVIEPSEFVKIMEPLFRQLAK
CVSSPHFQVAERALYYWNNEYIMSLISDNAAKILPIMFPSLYRNSKTHWNKTIHGLIYNA
LKLFMEMNQKLFDDCTQQFKAEKLKEKLKMKEREEAWVKIENL
Sequence of entity 3 (C), FASTA
>3FGA_3 Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (chains C)
MDEKVFTKELDQWIEQLNECKQLSESQVKSLCEKAKEILTKESNVQEVRCPVTVCGDVHG
QFHDLMELFRIGGKSPDTNYLFMGDYVNRGYYSVETVTLLVALKVRYRERITILRGNHES
RQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHI
RALDRLQEVPHEGPMCDLLWSDPDDRGGWGISPRGAGYTFGQDISETFNHANGLTLVSRA
HQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPAPRRGEPHV
TRRTPDYFL
Sequence of entity 4 (D), FASTA
>3FGA_4 Shugoshin-like 1 (chains D)
PSTLLKNYQDNNKMLVLALENEKSKVKEAQDIILQLRKECYYLTCQL
Sequence of entity 5 (E), FASTA
>3FGA_5 MICROCYSTIN-LR (chains E)
ALDRXEX

Ligands and cofactors

IDNameFormulaCopies
MNManganese (II) ionMn2

Primary citation

Structure and function of the PP2A-shugoshin interaction. Xu, Z., Cetin, B., Anger, M. et al. Mol Cell (2009) 35:426-441. DOI 10.1016/j.molcel.2009.06.031 · PubMed

Other PDB entries of the same protein (UniProt Q76MZ3 (AlphaFold model), which also has an AlphaFold model), best resolution first:

Browse structure collections

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