Elongation factor 1-alpha 1 (EEF1A1) is a 462-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P68104.
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The mean pLDDT of this model is 88.1 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 59% |
| 70 to 90 | Confident: backbone generally right | 36% |
| 50 to 70 | Low: treat with caution | 5% |
| Below 50 | Very low: often disordered regions | 0% |
What pLDDT means and how to read it
Translation elongation factor that catalyzes the GTP-dependent binding of aminoacyl-tRNA (aa-tRNA) to the A-site of ribosomes during the elongation phase of protein synthesis (PubMed:26593721, PubMed:26651998, PubMed:36123449, PubMed:36264623, PubMed:36638793). Base pairing between the mRNA codon and the aa-tRNA anticodon promotes GTP hydrolysis, releasing the aa-tRNA from EEF1A1 and allowing its accommodation into the ribosome (PubMed:26593721, PubMed:26651998, PubMed:36123449, PubMed:36264623, PubMed:36638793). The growing protein chain is subsequently transferred from the P-site peptidyl tRNA to the A-site aa-tRNA, extending it by one amino acid through ribosome-catalyzed peptide bond…
Found in a nuclear export complex with XPO5, EEF1A1, Ran and aminoacylated tRNA (PubMed:12426392, PubMed:12426393). Interacts with PARP1 (PubMed:17177976). Interacts with KARS1 (PubMed:18029264). May interact with ERGIC2 (PubMed:17980171). Interacts with IFIT1 (via TPR repeats 4-7) (By similarity). Interacts with DLC1, facilitating distribution to the membrane periphery and ruffles upon growth…
Cytoplasm, Nucleus, Nucleus, nucleolus, Cell membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 3C5J | X-ray | 1.8 Å | C=343-355 |
| 9P8B | EM | 2.48 Å | CF=4-444 |
| 8G60 | EM | 2.54 Å | EF=1-462 |
| 9P7O | EM | 2.65 Å | CF=4-444 |
| 9PA7 | EM | 2.67 Å | CF=4-444 |
| 8G6J | EM | 2.8 Å | EF=1-462 |
| 9P7K | EM | 2.8 Å | CF=4-444 |
| 9P76 | EM | 2.83 Å | CF=4-444 |
| 9P7N | EM | 2.83 Å | CF=4-444 |
| 9P7L | EM | 2.92 Å | CF=4-444 |
| 6ZMO | EM | 3.1 Å | CD=1-462 |
| 9P7H | EM | 3.68 Å | CF=4-444 |
| 9P7I | EM | 3.69 Å | CF=4-444 |
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