6ZMO: SARS-CoV-2 Nsp1
SARS-CoV-2 Nsp1 bound to the human LYAR-80S-eEF1a ribosome complex. Determined by electron microscopy at 3.1 Å resolution. Released 19 Aug 2020.
- Method
- Electron microscopy
- Resolution
- 3.1 Å
- Organisms
- Homo sapiens, Severe acute respiratory syndrome coronavirus 2
- Chains
- 88
- Atoms
- 230,351
- Mol. weight
- 4072.34 kDa
- Ligands
- ZN, MG
- Released
- 19 Aug 2020
Explore 6ZMO in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
6ZMO contains 537 α-helices and 626 β-strands across 82 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chain CA: 10 helices, 25 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 15-38 | 24 | |
| β-strand | 44 | 1 | 47 |
| α-helix | 45-62 | 18 | |
| β-strand | 72-76 | 5 | 48 |
| β-strand | 85 | 1 | 49 |
| β-strand | 99 | 1 | 47 |
| β-strand | 105-114 | 10 | 48 |
| β-strand | 117-126 | 10 | 48 |
| α-helix | 129-130 | 2 | |
| β-strand | 135 | 1 | 50 |
| α-helix | 138-156 | 19 | |
| β-strand | 159 | 1 | 51 |
| β-strand | 161 | 1 | 51 |
| β-strand | 162 | 1 | 52 |
| α-helix | 163-176 | 14 | |
| β-strand | 180-181 | 2 | 48 |
| β-strand | 185-190 | 6 | 48 |
| β-strand | 191 | 1 | 53 |
| β-strand | 194 | 1 | 53 |
| β-strand | 200-203 | 4 | 48 |
| α-helix | 207-211 | 5 | |
| β-strand | 217 | 1 | 52 |
| β-strand | 222-231 | 10 | 48 |
| β-strand | 238 | 1 | 49 |
| α-helix | 242-244 | 3 | |
| β-strand | 246-249 | 4 | 54 |
| α-helix | 260-272 | 13 | |
| β-strand | 278 | 1 | 54 |
| α-helix | 287-298 | 12 | |
| β-strand | 302-305 | 4 | 54 |
| β-strand | 309 | 1 | 49 |
| β-strand | 316-326 | 11 | 48 |
| β-strand | 329-331 | 3 | 48 |
| β-strand | 343 | 1 | 50 |
| α-helix | 352-359 | 8 | |
Chain CD: 14 helices, 31 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 9-14 | 6 | 73 |
| α-helix | 20-31 | 12 | |
| α-helix | 36-49 | 14 | |
| α-helix | 52-54 | 3 | |
| α-helix | 55-60 | 6 | |
| α-helix | 64-69 | 6 | |
| β-strand | 76-81 | 6 | 73 |
| β-strand | 86-91 | 6 | 73 |
| α-helix | 99-107 | 9 | |
| β-strand | 111-117 | 7 | 73 |
| α-helix | 122-126 | 5 | |
| α-helix | 133-143 | 11 | |
| β-strand | 148-153 | 6 | 73 |
| α-helix | 164-181 | 18 | |
| β-strand | 190-193 | 4 | 73 |
| β-strand | 194 | 1 | 74 |
| β-strand | 199 | 1 | 74 |
| β-strand | 214-217 | 4 | 75 |
| β-strand | 222-225 | 4 | 75 |
| α-helix | 228-233 | 6 | |
| α-helix | 235-237 | 3 | |
| α-helix | 245-246 | 2 | |
| β-strand | 247-249 | 3 | 76 |
| β-strand | 252-256 | 5 | 77 |
| β-strand | 260-267 | 8 | 77 |
| β-strand | 272 | 1 | 78 |
| β-strand | 277-280 | 4 | 76 |
| β-strand | 285-288 | 4 | 76 |
| β-strand | 289-293 | 5 | 77 |
| β-strand | 298-299 | 2 | 77 |
| β-strand | 302 | 1 | 78 |
| β-strand | 306-312 | 7 | 77 |
| β-strand | 325-328 | 4 | 76 |
| α-helix | 332-334 | 3 | |
| β-strand | 337 | 1 | 79 |
| β-strand | 340-346 | 7 | 80 |
| α-helix | 359 | 1 | |
| β-strand | 360-362 | 3 | 80 |
| β-strand | 367-375 | 9 | 80 |
| β-strand | 377-379 | 3 | 80 |
| β-strand | 386-389 | 4 | 80 |
| β-strand | 399-406 | 8 | 80 |
| β-strand | 410 | 1 | 79 |
| β-strand | 423-428 | 6 | 80 |
| β-strand | 431-441 | 11 | 80 |
Chain CE: 4 helices, 3 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 311-320 | 10 | |
| α-helix | 323-325 | 3 | |
| β-strand | 326-328 | 3 | 90 |
| α-helix | 329-343 | 15 | |
| α-helix | 351-364 | 14 | |
| β-strand | 368-371 | 4 | 90 |
| β-strand | 374-377 | 4 | 90 |
Chain i: 2 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 153-159 | 7 | |
| α-helix | 166-178 | 13 | |
Chain La: 10 helices, 8 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 3-5 | 3 | |
| α-helix | 7-11 | 5 | |
| α-helix | 42-48 | 7 | |
| β-strand | 53 | 1 | 155 |
| β-strand | 72-73 | 2 | 19 |
| α-helix | 75-78 | 4 | |
| α-helix | 79-81 | 3 | |
| α-helix | 84-91 | 8 | |
| α-helix | 97 | 1 | |
| β-strand | 98 | 1 | 123 |
| α-helix | 99 | 1 | |
| β-strand | 100-102 | 3 | 20 |
| α-helix | 103-106 | 4 | |
| β-strand | 110-111 | 2 | 19 |
| β-strand | 123-126 | 4 | 20 |
| β-strand | 128-129 | 2 | 19 |
| α-helix | 131-140 | 10 | |
| β-strand | 143-146 | 4 | 20 |
Chain LA: 10 helices, 22 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 8-12 | 5 | |
| β-strand | 18 | 1 | 23 |
| α-helix | 34-38 | 5 | |
| β-strand | 40-49 | 10 | 24 |
| α-helix | 50-51 | 2 | |
| β-strand | 58-64 | 7 | 24 |
| β-strand | 71-77 | 7 | 24 |
| α-helix | 78 | 1 | |
| β-strand | 79 | 1 | 25 |
| β-strand | 83 | 1 | 26 |
| β-strand | 86-91 | 6 | 24 |
| β-strand | 101-103 | 3 | 24 |
| β-strand | 111-113 | 3 | 27 |
| β-strand | 116 | 1 | 28 |
| β-strand | 120 | 1 | 29 |
| β-strand | 122 | 1 | 29 |
| β-strand | 126 | 1 | 28 |
| β-strand | 134-140 | 7 | 27 |
| α-helix | 142-144 | 3 | |
| β-strand | 145-150 | 6 | 27 |
| β-strand | 154-159 | 6 | 27 |
| β-strand | 163-165 | 3 | 24 |
| β-strand | 166 | 1 | 27 |
| β-strand | 169 | 1 | 25 |
| α-helix | 174-176 | 3 | |
| α-helix | 182-192 | 11 | |
| β-strand | 193 | 1 | 23 |
| α-helix | 198-200 | 3 | |
| α-helix | 201-203 | 3 | |
| β-strand | 224-225 | 2 | 30 |
| α-helix | 229-230 | 2 | |
| β-strand | 237-238 | 2 | 30 |
Chain Lb: 6 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 12-18 | 7 | |
| α-helix | 22-24 | 3 | |
| α-helix | 37-48 | 12 | |
| α-helix | 54-73 | 20 | |
| α-helix | 92-99 | 8 | |
| α-helix | 106-116 | 11 | |
Chain LB: 19 helices, 22 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 9-10 | 2 | |
| α-helix | 14-16 | 3 | |
| α-helix | 32-35 | 4 | |
| α-helix | 40-41 | 2 | |
| β-strand | 42-43 | 2 | 37 |
| β-strand | 45-59 | 15 | 38 |
| β-strand | 60 | 1 | 39 |
| β-strand | 68 | 1 | 39 |
| β-strand | 71-80 | 10 | 38 |
| α-helix | 82-83 | 2 | |
| β-strand | 84-95 | 12 | 40 |
| β-strand | 98-106 | 9 | 40 |
| α-helix | 107 | 1 | |
| α-helix | 112-118 | 7 | |
| α-helix | 131-138 | 8 | |
| α-helix | 142-156 | 15 | |
| β-strand | 159-165 | 7 | 40 |
| α-helix | 168-170 | 3 | |
| α-helix | 177-179 | 3 | |
| β-strand | 180-184 | 5 | 40 |
| β-strand | 185-186 | 2 | 37 |
| α-helix | 190-199 | 10 | |
| β-strand | 203-205 | 3 | 40 |
| α-helix | 207-210 | 4 | |
| β-strand | 216-222 | 7 | 38 |
| α-helix | 223-225 | 3 | |
| β-strand | 227-229 | 3 | 41 |
| α-helix | 231-234 | 4 | |
| α-helix | 237-241 | 5 | |
| β-strand | 270-272 | 3 | 41 |
| β-strand | 276-287 | 12 | 38 |
| β-strand | 292 | 1 | 42 |
| β-strand | 298 | 1 | 42 |
| α-helix | 315-316 | 2 | |
| β-strand | 320 | 1 | 43 |
| β-strand | 324 | 1 | 43 |
| β-strand | 330-334 | 5 | 38 |
| β-strand | 343-349 | 7 | 38 |
| β-strand | 365-368 | 4 | 38 |
| α-helix | 382-389 | 8 | |
| α-helix | 393-401 | 9 | |
74 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| 28S ribosomal RNA | L5 | RNA | 5066 | Homo sapiens | |
| 5S ribosomal RNA | L7 | RNA | 121 | Homo sapiens | |
| 5.8S ribosomal RNA | L8 | RNA | 157 | Homo sapiens | |
| 60S ribosomal protein L8 | LA | protein | 257 | Homo sapiens | P62917 (AlphaFold model) |
| 60S ribosomal protein L3 | LB | protein | 403 | Homo sapiens | P39023 (AlphaFold model) |
| 60S ribosomal protein L4 | LC | protein | 427 | Homo sapiens | P36578 (AlphaFold model) |
| 60S ribosomal protein L5 | LD | protein | 297 | Homo sapiens | P46777 (AlphaFold model) |
| 60S ribosomal protein L6 | LE | protein | 288 | Homo sapiens | Q02878 |
| 60S ribosomal protein L7 | LF | protein | 248 | Homo sapiens | P18124 |
| 60S ribosomal protein L7a | LG | protein | 266 | Homo sapiens | P62424 |
| 60S ribosomal protein L9 | LH | protein | 192 | Homo sapiens | P32969 |
| 60S ribosomal protein L10-like | LI | protein | 214 | Homo sapiens | Q96L21 |
76 more molecules are not listed.
Sequence of entity 1 (L5), FASTA
>6ZMO_1 28S ribosomal RNA (chains L5)
CGCGACCUCAGAUCAGACGUGGCGACCCGCUGAAUUUAAGCAUAUUAGUCAGCGGAGGAG
AAGAAACUAACCAGGAUUCCCUCAGUAACGGCGAGUGAACAGGGAAGAGCCCAGCGCCGA
AUCCCCGCCCCGCGGCGGGGCGCGGGACAUGUGGCGUACGGAAGACCCGCUCCCCGGCGC
CGCUCGUGGGGGGCCCAAGUCCUUCUGAUCGAGGCCCAGCCCGUGGACGGUGUGAGGCCG
GUAGCGGCCCCCGGCGCGCCGGGCCCGGGUCUUCCCGGAGUCGGGUUGCUUGGGAAUGCA
GCCCAAAGCGGGUGGUAAACUCCAUCUAAGGCUAAAUACCGGCACGAGACCGAUAGUCAA
CAAGUACCGUAAGGGAAAGUUGAAAAGAACUUUGAAGAGAGAGUUCAAGAGGGCGUGAAA
CCGUUAAGAGGUAAACGGGUGGGGUCCGCGCAGUCCGCCCGGAGGAUUCAACCCGGCGGC
GGGUCCGGCCGUGUCGGCGGCCCGGCGGAUCUUUCCCGCCCCCCGUUCCUCCCGACCCCU
CCACCCGCCCUCCCUUCCCCCGCCGCCCCUCCUCCUCCUCCCCGGAGGGGGCGGGCUCCG
GCGGGUGCGGGGGUGGGCGGGCGGGGCCGGGGGUGGGGUCGGCGGGGGACCGUCCCCCGA
CCGGCGACCGGCCGCCGCCGGGCGCAUUUCCACCGCGGCGGUGCGCCGCGACCGGCUCCG
GGACGGCUGGGAAGGCCCGGCGGGGAAGGUGGCUCGGGGGGCCCCGUCCGUCCGUCCGUC
CGUCCUCCUCCUCCCCCGUCUCCGCCCCCCGGCCCCGCGUCCUCCCUCGGGAGGGCGCGC
GGGUCGGGGCGGCGGCGGCGGCGGCGGUGGCGGCGGCGGCGGCGGCGGCGGGACCGAAAC
CCCCCCCGAGUGUUACAGCCCCCCCGGCAGCAGCACUCGCCGAAUCCCGGGGCCGAGGGA
GCGAGACCCGUCGCCGCGCUCUCCCCCCUCCCGGCGCCCACCCCCGCGGGGAAUCCCCCG
CGAGGGGGGUCUCCCCCGCGGGGGCGCGCCGGCGUCUCCUCGUGGGGGGGCCGGGCCACC
CCUCCCACGGCGCGACCGCUCUCCCACCCCUCCUCCCCGCGCCCCCGCCCCGGCGACGGG
GGGGGUGCCGCGCGCGGGUCGGGGGGCGGGGCGGACUGUCCCCAGUGCGCCCCGGGCGGG
UCGCGCCGUCGGGCCCGGGGGAGGUUCUCUCGGGGCCACGCGCGCGUCCCCCGAAGAGGG
GGACGGCGGAGCGAGCGCACGGGGUCGGCGGCGACGUCGGCUACCCACCCGACCCGUCUU
GAAACACGGACCAAGGAGUCUAACACGUGCGCGAGUCGGGGGCUCGCACGAAAGCCGCCG
UGGCGCAAUGAAGGUGAAGGCCGGCGCGCUCGCCGGCCGAGGUGGGAUCCCGAGGCCUCU
CCAGUCCGCCGAGGGCGCACCACCGGCCCGUCUCGCCCGCCGCGCCGGGGAGGUGGAGCA
CGAGCGCACGUGUUAGGACCCGAAAGAUGGUGAACUAUGCCUGGGCAGGGCGAAGCCAGA
GGAAACUCUGGUGGAGGUCCGUAGCGGUCCUGACGUGCAAAUCGGUCGUCCGACCUGGGU
AUAGGGGCGAAAGACUAAUCGAACCAUCUAGUAGCUGGUUCCCUCCGAAGUUUCCCUCAG
GAUAGCUGGCGCUCUCGCAGACCCGACGCACCCCCGCCACGCAGUUUUAUCCGGUAAAGC
GAAUGAUUAGAGGUCUUGGGGCCGAAACGAUCUCAACCUAUUCUCAAACUUUAAAUGGGU
AAGAAGCCCGGCUCGCUGGCGUGGAGCCGGGCGUGGAAUGCGAGUGCCUAGUGGGCCACU
UUUGGUAAGCAGAACUGGCGCUGCGGGAUGAACCGAACGCCGGGUUAAGGCGCCCGAUGC
CGACGCUCAUCAGACCCCAGAAAAGGUGUUGGUUGAUAUAGACAGCAGGACGGUGGCCAU
GGAAGUCGGAAUCCGCUAAGGAGUGUGUAACAACUCACCUGCCGAAUCAACUAGCCCUGA
AAAUGGAUGGCGCUGGAGCGUCGGGCCCAUACCCGGCCGUCGCCGGCAGUCGAGAGUGGA
CGGGAGCGGCGGGGGCGGCGCGCGCGCGCGCGCGUGUGGUGUGCGUCGGAGGGCGGCGGC
GGCGGCGGCGGCGGGGGUGUGGGGUCCUUCCCCCGCCCCCCCCCCCACGCCUCCUCCCCU
CCUCCCGCCCACGCCCCGCUCCCCGCCCCCGGAGCCCCGCGGACGCUACGCCGCGACGAG
UAGGAGGGCCGCUGCGGUGAGCCUUGAAGCCUAGGGCGCGGGCCCGGGUGGAGCCGCCGC
AGGUGCAGAUCUUGGUGGUAGUAGCAAAUAUUCAAACGAGAACUUUGAAGGCCGAAGUGG
AGAAGGGUUCCAUGUGAACAGCAGUUGAACAUGGGUCAGUCGGUCCUGAGAGAUGGGCGA
GCGCCGUUCCGAAGGGACGGGCGAUGGCCUCCGUUGCCCUCGGCCGAUCGAAAGGGAGUC
GGGUUCAGAUCCCCGAAUCCGGAGUGGCGGAGAUGGGCGCCGCGAGGCGUCCAGUGCGGU
AACGCGACCGAUCCCGGAGAAGCCGGCGGGAGCCCCGGGGAGAGUUCUCUUUUCUUUGUG
AAGGGCAGGGCGCCCUGGAAUGGGUUCGCCCCGAGAGAGGGGCCCGUGCCUUGGAAAGCG
UCGCGGUUCCGGCGGCGUCCGGUGAGCUCUCGCUGGCCCUUGAAAAUCCGGGGGAGAGGG
UGUAAAUCUCGCGCCGGGCCGUACCCAUAUCCGCAGCAGGUCUCCAAGGUGAACAGCCUC
UGGCAUGUUGGAACAAUGUAGGUAAGGGAAGUCGGCAAGCCGGAUCCGUAACUUCGGGAU
AAGGAUUGGCUCUAAGGGCUGGGUCGGUCGGGCUGGGGCGCGAAGCGGGGCUGGGCGCGC
GCCGCGGCUGGACGAGGCGCCGCCGCCCCCCCCACGCCCGGGGCACCCCCCUCGCGGCCC
UCCCCCGCCCCACCCCGCGCGCGCCGCUCGCUCCCUCCCCGCCCCGCGCCCUCUCUCUCU
CUCUCUCCCCCGCUCCCCGUCCUCCCCCCUCCCCGGGGGAGCGCCGCGUGGGGGCGGCGG
CGGGGGGAGAAGGGUCGGGGCGGCAGGGGCCGGCGGCGGCCCGCCGCGGGGCCCCGGCGG
CGGGGGCACGGUCCCCCGCGAGGGGGGCCCGGGCACCCGGGGGGCCGGCGGCGGCGGCGA
CUCUGGACGCGAGCCGGGCCCUUCCCGUGGAUCGCCCCAGCUGCGGCGGGCGUCGCGGCC
GCCCCCGGGGAGCCCGGCGGGCGCCGGCGCGCCCCCCCCCCCACCCCACGUCUCGUCGCG
CGCGCGUCCGCUGGGGGCGGGGAGCGGUCGGGCGGCGGCGGUCGGCGGGCGGCGGGGCGG
GGCGGUUCGUCCCCCCGCCCUACCCCCCCGGCCCCGUCCGCCCCCCGUUCCCCCCUCCUC
CUCGGCGCGCGGCGGCGGCGGCGGGCGGCGGAGGGGCCGCGGGCCGGUCCCCCCCGCCGG
GUCCGCCCCCGGGGCCGCGGUUCCGCGCGGCGCCUCGCCUCGGCCGGCGCCUAGCAGCCG
ACUUAGAACUGGUGCGGACCAGGGGAAUCCGACUGUUUAAUUAAAACAAAGCAUCGCGAA
GGCCCGCGGCGGGUGUUGACGCGAUGUGAUUUCUGCCCAGUGCUCUGAAUGUCAAAGUGA
AGAAAUUCAAUGAAGCGCGGGUAAACGGCGGGAGUAACUAUGACUCUCUUAAGGUAGCCA
AAUGCCUCGUCAUCUAAUUAGUGACGCGCAUGAAUGGAUGAACGAGAUUCCCACUGUCCC
UACCUACUAUCCAGCGAAACCACAGCCAAGGGAACGGGCUUGGCGGAAUCAGCGGGGAAA
GAAGACCCUGUUGAGCUUGACUCUAGUCUGGCACGGUGAAGAGACAUGAGAGGUGUAGAA
UAAGUGGGAGGCCCCCGGCGCCCCCCCGGUGUCCCCGCGAGGGGCCCGGGGCGGGGUCCG
CCGGCCCUGCGGGCCGCCGGUGAAAUACCACUACUCUGAUCGUUUUUUCACUGACCCGGU
GAGGCGGGGGGGCGAGCCCCGAGGGGCUCUCGCUUCUGGCGCCAAGCGCCCGGCCGCGCG
CCGGCCGGGCGCGACCCGCUCCGGGGACAGUGCCAGGUGGGGAGUUUGACUGGGGCGGUA
CACCUGUCAAACGGUAACGCAGGUGUCCUAAGGCGAGCUCAGGGAGGACAGAAACCUCCC
GUGGAGCAGAAGGGCAAAAGCUCGCUUGAUCUUGAUUUUCAGUACGAAUACAGACCGUGA
AAGCGGGGCCUCACGAUCCUUCUGACCUUUUGGGUUUUAAGCAGGAGGUGUCAGAAAAGU
UACCACAGGGAUAACUGGCUUGUGGCGGCCAAGCGUUCAUAGCGACGUCGCUUUUUGAUC
CUUCGAUGUCGGCUCUUCCUAUCAUUGUGAAGCAGAAUUCACCAAGCGUUGGAUUGUUCA
CCCACUAAUAGGGAACGUGAGCUGGGUUUAGACCGUCGUGAGACAGGUUAGUUUUACCCU
ACUGAUGAUGUGUUGUUGCCAUGGUAAUCCUGCUCAGUACGAGAGGAACCGCAGGUUCAG
ACAUUUGGUGUAUGUGCUUGGCUGAGGAGCCAAUGGGGCGAAGCUACCAUCUGUGGGAUU
AUGACUGAACGCCUCUAAGUCAGAAUCCCGCCCAGGCGGAACGAUACGGCAGCGCCGCGG
AGCCUCGGUUGGCCUCGGAUAGCCGGUCCCCCGCCUGUCCCCGCCGGCGGGCCGCCCCCC
CCUCCACGCGCCCCGCGCGCGCGGGAGGGCGCGUGCCCCGCCGCGCGCCGGGACCGGGGU
CCGGUGCGGAGUGCCCUUCGUCCUGGGAAACGGGGCGCGGCUGGAAAGGCGGCCGCCCCC
UCGCCCGUCACGCACCGCACGUUCGUGGGGAACCUGGCGCUAAACCAUUCGUAGACGACC
UGCUUCUGGGUCGGGGUUUC
Sequence of entity 2 (L7), FASTA
>6ZMO_2 5S ribosomal RNA (chains L7)
GUCUACGGCCAUACCACCCUGAACGCGCCCGAUCUCGUCUGAUCUCGGAAGCUAAGCAGG
GUCGGGCCUGGUUAGUACUUGGAUGGGAGACCGCCUGGGAAUACCGGGUGCUGUAGGCUU
U
Sequence of entity 3 (L8), FASTA
>6ZMO_3 5.8S ribosomal RNA (chains L8)
CGACUCUUAGCGGUGGAUCACUCGGCUCGUGCGUCGAUGAAGAACGCAGCUAGCUGCGAG
AAUUAAUGUGAAUUGCAGGACACAUUGAUCAUCGACACUUCGAACGCACUUGCGGCCCCG
GGUUCCUCCCGGGGCUACGCCUGUCUGAGCGUCGCUU
Sequence of entity 4 (LA), FASTA
>6ZMO_4 60S ribosomal protein L8 (chains LA)
MGRVIRGQRKGAGSVFRAHVKHRKGAARLRAVDFAERHGYIKGIVKDIIHDPGRGAPLAK
VVFRDPYRFKKRTELFIAAEGIHTGQFVYCGKKAQLNIGNVLPVGTMPEGTIVCCLEEKP
GDRGKLARASGNYATVISHNPETKKTRVKLPSGSKKVISSANRAVVGVVAGGGRIDKPIL
KAGRAYHKYKAKRNCWPRVRGVAMNPVEHPFGGGNHQHIGKPSTIRRDAPAGRKVGLIAA
RRTGRLRGTKTVQEKEN
Sequence of entity 5 (LB), FASTA
>6ZMO_5 60S ribosomal protein L3 (chains LB)
MSHRKFSAPRHGSLGFLPRKRSSRHRGKVKSFPKDDPSKPVHLTAFLGYKAGMTHIVREV
DRPGSKVNKKEVVEAVTIVETPPMVVVGIVGYVETPRGLRTFKTVFAEHISDECKRRFYK
NWHKSKKKAFTKYCKKWQDEDGKKQLEKDFSSMKKYCQVIRVIAHTQMRLLPLRQKKAHL
MEIQVNGGTVAEKLDWARERLEQQVPVNQVFGQDEMIDVIGVTKGKGYKGVTSRWHTKKL
PRKTHRGLRKVACIGAWHPARVAFSVARAGQKGYHHRTEINKKIYKIGQGYLIKDGKLIK
NNASTDYDLSDKSINPLGGFVHYGEVTNDFVMLKGCVVGTKKRVLTLRKSLLVQTKRRAL
EKIDLKFIDTTSKFGHGRFQTMEEKKAFMGPLKKDRIAKEEGA
Sequence of entity 6 (LC), FASTA
>6ZMO_6 60S ribosomal protein L4 (chains LC)
MACARPLISVYSEKGESSGKNVTLPAVFKAPIRPDIVNFVHTNLRKNNRQPYAVSELAGH
QTSAESWGTGRAVARIPRVRGGGTHRSGQGAFGNMCRGGRMFAPTKTWRRWHRRVNTTQK
RYAICSALAASALPALVMSKGHRIEEVPELPLVVEDKVEGYKKTKEAVLLLKKLKAWNDI
KKVYASQRMRAGKGKMRNRRRIQRRGPCIIYNEDNGIIKAFRNIPGITLLNVSKLNILKL
APGGHVGRFCIWTESAFRKLDELYGTWRKAASLKSNYNLPMHKMINTDLSRILKSPEIQR
ALRAPRKKIHRRVLKKNPLKNLRIMLKLNPYAKTMRRNTILRQARNHKLRVDKAAAAAAA
LQAKSDEKAAVAGKKPVVGKKGKKAAVGVKKQKKPLVGKKAAATKKPAPEKKPAEKKPTT
EEKKPAA
Sequence of entity 7 (LD), FASTA
>6ZMO_7 60S ribosomal protein L5 (chains LD)
MGFVKVVKNKAYFKRYQVKFRRRREGKTDYYARKRLVIQDKNKYNTPKYRMIVRVTNRDI
ICQIAYARIEGDMIVCAAYAHELPKYGVKVGLTNYAAAYCTGLLLARRLLNRFGMDKIYE
GQVEVTGDEYNVESIDGQPGAFTCYLDAGLARTTTGNKVFGALKGAVDGGLSIPHSTKRF
PGYDSESKEFNAEVHRKHIMGQNVADYMRYLMEEDEDAYKKQFSQYIKNSVTPDMMEEMY
KKAHAAIRENPVYEKKPKKEVKKKRWNRPKMSLAQKKDRVAQKKASFLRAQERAAES
Sequence of entity 8 (LE), FASTA
>6ZMO_8 60S ribosomal protein L6 (chains LE)
MAGEKVEKPDTKEKKPEAKKVDAGGKVKKGNLKAKKPKKGKPHCSRNPVLVRGIGRYSRS
AMYSRKAMYKRKYSAAKSKVEKKKKEKVLATVTKPVGGDKNGGTRVVKLRKMPRYYPTED
VPRKLLSHGKKPFSQHVRKLRASITPGTILIILTGRHRGKRVVFLKQLASGLLLVTGPLV
LNRVPLRRTHQKFVIATSTKIDISNVKIPKHLTDAYFKKKKLRKPRHQEGEIFDTEKEKY
EITEQRKIDQKAVDSQILPKIKAIPQLQGYLRSVFALTNGIYPHKLVF
Sequence of entity 9 (LF), FASTA
>6ZMO_9 60S ribosomal protein L7 (chains LF)
MEGVEEKKKEVPAVPETLKKKRRNFAELKIKRLRKKFAQKMLRKARRKLIYEKAKHYHKE
YRQMYRTEIRMARMARKAGNFYVPAEPKLAFVIRIRGINGVSPKVRKVLQLLRLRQIFNG
TFVKLNKASINMLRIVEPYIAWGYPNLKSVNELIYKRGYGKINKKRIALTDNALIARSLG
KYGIICMEDLIHEIYTVGKRFKEANNFLWPFKLSSPRGGMKKKTTHFVEGGDAGNREDQI
NRLIRRMN
Sequence of entity 10 (LG), FASTA
>6ZMO_10 60S ribosomal protein L7a (chains LG)
MPKGKKAKGKKVAPAPAVVKKQEAKKVVNPLFEKRPKNFGIGQDIQPKRDLTRFVKWPRY
IRLQRQRAILYKRLKVPPAINQFTQALDRQTATQLLKLAHKYRPETKQEKKQRLLARAEK
KAAGKGDVPTKRPPVLRAGVNTVTTLVENKKAQLVVIAHDVDPIELVVFLPALCRKMGVP
YCIIKGKARLGRLVHRKTCTTVAFTQVNSEDKGALAKLVEAIRTNYNDRYDEIRRHWGGN
VLGPKSVARIAKLEKAKAKELATKLG
Sequence of entity 11 (LH), FASTA
>6ZMO_11 60S ribosomal protein L9 (chains LH)
MKTILSNQTVDIPENVDITLKGRTVIVKGPRGTLRRDFNHINVELSLLGKKKKRLRVDKW
WGNRKELATVRTICSHVQNMIKGVTLGFRYKMRSVYAHFPINVVIQENGSLVEIRNFLGE
KYIRRVRMRPGVACSVSQAQKDELILEGNDIELVSNSAALIQQATTVKNKDIRKFLDGIY
VSEKGTVQQADE
Sequence of entity 12 (LI), FASTA
>6ZMO_12 60S ribosomal protein L10-like (chains LI)
MGRRPARCYRYCKNKPYPKSRFCRGVPDAKIRIFDLGRKKAKVDEFPLGGHMVSDEYEQL
SSEALEAARICANKYMVKSCGRDGFHMRVRLHPFHVIRINKMLSCAGADRLQTGMRGAFG
KPQGTVARVHIGQVIMSIRTKLQNEEHVIEALRRAKFKFPGRQKIHISKKWGFTKFNADE
FEDMVAKKCLIPDGCGVKYVPSHGPLDKWRVLHS
Ligands and cofactors
| ID | Name | Formula | Copies |
|---|
| ZN | Zinc ion | Zn | 8 |
| MG | Magnesium ion | Mg | 256 |
Primary citation
Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2. Thoms, M., Buschauer, R., Ameismeier, M. et al. Science (2020) 369:1249-1255. DOI 10.1126/science.abc8665 · PubMed
Other PDB entries of the same protein (UniProt P62917 (AlphaFold model), which also has an AlphaFold model), best resolution first:
- 8A3D 1.67 Å, Human mature large subunit of the ribosome with eIF6 and homoharringtonine bound
- 29IW 1.77 Å, Human monosomes with bound toxin NT-2, focus on 60S subunit. Cells treated with NT-2.
- 8QYX 1.78 Å, Human 60S ribosomal subunit
- 8QOI 1.9 Å, Structure of the human 80S ribosome at 1.9 A resolution - the molecular role of chemical…
- 9O3W 1.9 Å, Human 80S ribosome bound to IDB-001 stalled on MYC nascent chain
- 8YOO 2.0 Å, Cryo-EM structure of the human 80S ribosome with 100 um Tigecycline
- 9C3H 2.0 Å, Structure of the CNOT3-bound human 80S ribosome with tRNA-ARG in the P-site.
- 29IZ 2.08 Å, Dormant 80S:eEF2:SERBP1:tRNA complex from human cells treated with toxin NT-2
- 9TV2 2.1 Å, 80S ribosomes from primary B-cells infected with delta v-snoRNA1 EBV
- 9I2D 2.19 Å, NMT1-NAC bound human RNC with 10 amino acid ARF1-linker
- 9PBE 2.19 Å, In situ human 80S ribosome (composite map)
- 29IX 2.2 Å, Human monosomes with bound toxin NT-2, focus on 60S subunit. NT-2 added to purified…
Browse structure collections
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