Casein kinase II subunit alpha (CSNK2A1) is a 391-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P68400.
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The mean pLDDT of this model is 88.9 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 83% |
| 70 to 90 | Confident: backbone generally right | 2% |
| 50 to 70 | Low: treat with caution | 1% |
| Below 50 | Very low: often disordered regions | 13% |
What pLDDT means and how to read it
Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine (PubMed:11239457, PubMed:11704824, PubMed:16193064, PubMed:18411307, PubMed:18583988, PubMed:18678890, PubMed:19188443, PubMed:20545769, PubMed:20625391, PubMed:22017874, PubMed:22406621, PubMed:24962073, PubMed:30898438, PubMed:31439799). Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection (PubMed:12631575, PubMed:19387551, PubMed:19387552). May act as a regulatory node which integrates and coordinates…
Heterotetramer composed of two catalytic subunits (alpha chain and/or alpha' chain) and two regulatory subunits (beta chains). The tetramer can exist as a combination of 2 alpha/2 beta, 2 alpha'/2 beta or 1 alpha/1 alpha'/2 beta subunits. Also part of a CK2-SPT16-SSRP1 complex composed of SSRP1, SUPT16H, CSNK2A1, CSNK2A2 and CSNK2B, which forms following UV irradiation. Interacts with RNPS1.…
Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 3WAR | X-ray | 1.04 Å | A=1-335 |
| 5ZN1 | X-ray | 1.05 Å | A=1-329 |
| 8AEC | X-ray | 1.09 Å | A=2-329 |
| 5ZN0 | Other | 1.1 Å | A=1-329 |
| 7I7Y | X-ray | 1.15 Å | A=2-329 |
| 6YZH | X-ray | 1.19 Å | A=3-329 |
| 5ZN2 | X-ray | 1.2 Å | A=1-329 |
| 7I8G | X-ray | 1.23 Å | A=2-329 |
| 4KWP | X-ray | 1.25 Å | A=1-336 |
| 5CVG | X-ray | 1.25 Å | A=2-329 |
| 7I8P | X-ray | 1.25 Å | A=2-329 |
| 7I8N | X-ray | 1.28 Å | A=2-329 |
| 8AE7 | X-ray | 1.28 Å | A=2-329 |
| 3NSZ | X-ray | 1.3 Å | A=2-331 |
| 7I8M | X-ray | 1.31 Å | A=2-329 |
| 7I8O | X-ray | 1.31 Å | A=2-329 |
| 7ZWG | X-ray | 1.31 Å | A=2-329 |
| 7ZYK | X-ray | 1.31 Å | A=2-329 |
| 7I86 | X-ray | 1.32 Å | A=2-329 |
| 5OUL | X-ray | 1.34 Å | A=2-329 |
Showing 20 of 320 experimental structures (best resolution first).
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