Vesicle-associated membrane protein 7 (Vamp7) is a 220-residue protein from Mus musculus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P70280.
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The mean pLDDT of this model is 85.1 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 57% |
| 70 to 90 | Confident: backbone generally right | 27% |
| 50 to 70 | Low: treat with caution | 14% |
| Below 50 | Very low: often disordered regions | 2% |
What pLDDT means and how to read it
Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion. Required for calcium regulated lysosomal exocytosis. Involved in the export of chylomicrons from the endoplasmic reticulum to the cis Golgi. Required for exocytosis of mediators during eosinophil and neutrophil degranulation, and target cell killing by natural killer cells. Required for focal exocytosis of late endocytic vesicles during phagosome formation
Forms a SNARE complex composed of STX4, SNAP23 and VAMP7 that binds SYT7 during lysosomal exocytosis (By similarity). Forms a SNARE complex composed of STX7, STX8, VAMP7 and VTI1B that is required for heterotypic fusion of late endosomes with lysosomes (By similarity). May interact with STX17. Interacts with PICALM (By similarity). Interacts with RAB21 (By similarity)
Cytoplasmic vesicle, secretory vesicle membrane, Golgi apparatus, trans-Golgi network membrane, Late endosome membrane, Lysosome membrane, Endoplasmic reticulum membrane, Cytoplasmic vesicle, phagosome membrane, Synapse, synaptosome
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 4B93 | X-ray | 2.0 Å | A=1-188 |
| 2VX8 | X-ray | 2.2 Å | A/B/C/D=1-120 |
| 4AFI | X-ray | 2.8 Å | A/B=1-120 |
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