MyoD family inhibitor (Mdfi) is a 251-residue protein from Mus musculus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P70331.
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The mean pLDDT of this model is 54.2 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 0% |
| 70 to 90 | Confident: backbone generally right | 4% |
| 50 to 70 | Low: treat with caution | 70% |
| Below 50 | Very low: often disordered regions | 27% |
What pLDDT means and how to read it
Inhibits the transactivation activity of the Myod family of myogenic factors and represses myogenesis (PubMed:8797820). Acts by associating with Myod family members and retaining them in the cytoplasm by masking their nuclear localization signals (PubMed:8797820). Can also interfere with the DNA-binding activity of Myod family members (PubMed:8797820). Plays an important role in trophoblast and chondrogenic differentiation (PubMed:9799236). Regulates the transcriptional activity of TCF7L1/TCF3 by interacting directly with Tcf7l1/Tcf3 and preventing it from binding DNA (PubMed:11238923). Binds to the axin complex, resulting in an increase in the level of free beta-catenin (PubMed:12192039).…
Interacts (via C-terminus) with AXIN1 and LEF1 (PubMed:12192039). Interacts with CCNT2 (By similarity). Interacts (via C-terminus) with Piezo channel composed of PIEZO1 or PIEZO2; the interaction prolongs Piezo channel inactivation (PubMed:37590348)
Nucleus, Cytoplasm
UniProt lists no experimental PDB structure for this protein, so the AlphaFold prediction is the main 3D model available.
MolViewer loads the AlphaFold model straight from AlphaFold DB into your browser. Show it as a cartoon, color by pLDDT, measure distances and angles, and load a PDB structure next to it to compare.