C-C motif chemokine 7 (CCL7) is a 99-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P80098.
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The mean pLDDT of this model is 84.9 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 57% |
| 70 to 90 | Confident: backbone generally right | 23% |
| 50 to 70 | Low: treat with caution | 18% |
| Below 50 | Very low: often disordered regions | 2% |
What pLDDT means and how to read it
Chemotactic factor that plays an important role in immune regulation. Attracts monocytes, eosinophils, basophils, and T-cells to sites of inflammation or infection. Upon binding to various chemokine receptors including CCR1, CCR2, CCR3, and CCR5, facilitates immune cell migration by guiding them to infected tissues (PubMed:9364936, PubMed:10477718). Interacts with CCR2 to facilitate the release of monocytes from the bone marrow into the bloodstream, maintaining monocyte homeostasis. In turn, monocytes recruited to inflamed or injured tissues can differentiate into macrophages or dendritic cells, which are essential for immune defense and tissue repair. Through CCR1, contributes to…
Monomer. Interacts with TNFAIP6 (via Link domain)
Secreted
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 8FK6 | X-ray | 1.74 Å | B=24-99 |
| 7S58 | X-ray | 1.82 Å | E/F/H/J=24-99 |
| 7SCU | X-ray | 1.86 Å | B=24-99 |
| 8FK8 | X-ray | 1.96 Å | B=24-99 |
| 8FJ3 | X-ray | 2.07 Å | B=24-99 |
| 7S59 | X-ray | 2.39 Å | 2/4=41-99 |
| 4ZKC | X-ray | 3.15 Å | B=24-99 |
| 8JPS | EM | 3.65 Å | C/D=31-93 |
| 1BO0 | NMR | A=24-99 | |
| 1NCV | NMR | A/B=24-99 |
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