Protein crumbs homolog 1 (CRB1) is a 1406-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P82279.
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The mean pLDDT of this model is 75.1 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 13% |
| 70 to 90 | Confident: backbone generally right | 60% |
| 50 to 70 | Low: treat with caution | 17% |
| Below 50 | Very low: often disordered regions | 10% |
What pLDDT means and how to read it
Plays a role in photoreceptor morphogenesis in the retina (By similarity). May maintain cell polarization and adhesion (By similarity)
Component of a complex composed of PALS1, CRB1 and EPB41L5 (PubMed:17920587). Within the complex, interacts (via intracellular domain) with PALS1 and EPB41L5 (via FERM domain) (PubMed:17920587). Forms a complex with MPP4 and PALS1 (PubMed:15914641). Interacts with MPDZ/MUPP1 and MPP4 (By similarity)
Apical cell membrane, Secreted, Cell projection, cilium, photoreceptor outer segment, Photoreceptor inner segment
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 4UU5 | X-ray | 1.23 Å | B=1390-1406 |
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