Beta-theraphotoxin-Ps1a is a 34-residue protein from Paraphysa scrofa. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P84510.
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The mean pLDDT of this model is 92.8 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 91% |
| 70 to 90 | Confident: backbone generally right | 9% |
| 50 to 70 | Low: treat with caution | 0% |
| Below 50 | Very low: often disordered regions | 0% |
What pLDDT means and how to read it
Potent inhibitor of Nav1.2/SCN2A voltage-gated sodium channels (IC(50)=0.6-0.7 nM) (PubMed:16267209, PubMed:29703751). Also weakly inhibits Nav1.1/SCN1A, Nav1.4/SCN4A, Nav1.5/SCN5A, Nav1.7/SCN9A and Nav1.8/SCN10A (IC(50)=20-610 nM) (PubMed:16267209, PubMed:29703751). It acts by shifting the voltage dependence of channel activation to more depolarized potentials and by blocking the inward component of the sodium current (PubMed:16267209). It shows low affinity for lipid bilayers (PubMed:29703751). In vivo, this toxin causes general ataxia, lack of response to stimuli, and semiparalysis (PubMed:16267209). After a few minutes, the mice are unable to stand, and breathing is reduced in rhythm…
Secreted
Compare the prediction with experimentally determined structures of the same protein:
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