Apoptosis regulator Bcl-2 homolog (vBCL2) is a 171-residue protein from Murid herpesvirus 4. This is its AlphaFold structure prediction, created 1 Jan 2024. UniProt accession: P89884.
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The mean pLDDT of this model is 80.6 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 49% |
| 70 to 90 | Confident: backbone generally right | 27% |
| 50 to 70 | Low: treat with caution | 13% |
| Below 50 | Very low: often disordered regions | 12% |
What pLDDT means and how to read it
Plays a role in the protection against apoptosis mediated by cytotoxic cells during the immune response to acute and persistent viral infection. Contributes therefore to latency establishment. Plays also a role in the inhibition of host starvation-induced autophagy which ultimately contributes to the viral chronic infection
Interacts with host BECN1; this interaction inhibits host autophagy. Interacts with host BAK1 and BAX
Host cytoplasm
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 4MI8 | X-ray | 2.1 Å | A/B=2-136 |
| 3BL2 | X-ray | 2.3 Å | A/B=5-135 |
| 3DVU | X-ray | 2.5 Å | A/B=2-136 |
| 2ABO | NMR | A=1-136 |
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