ESAT-6-like protein EsxH (esxH) is a 96-residue protein from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv). This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P9WNK3.
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The mean pLDDT of this model is 89.3 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 67% |
| 70 to 90 | Confident: backbone generally right | 27% |
| 50 to 70 | Low: treat with caution | 4% |
| Below 50 | Very low: often disordered regions | 2% |
What pLDDT means and how to read it
EsxH, in complex with EsxG, disrupts ESCRT function and impairs host phagosome maturation, thereby promoting intracellular bacterial growth. The complex acts by interacting, via EsxH, with the host hepatocyte growth factor-regulated tyrosine kinase substrate (HGS/HRS), a component of the ESCRT machinery
Forms a tight 1:1 complex with EsxG (PubMed:15336430, PubMed:18430736, PubMed:19854905, PubMed:20085764, PubMed:21730061, PubMed:24204276). When it is complexed to EsxG, interacts directly with host HGS/HRS (PubMed:24204276)
Secreted
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6J29 | X-ray | 1.6 Å | C=3-11 |
| 7P4B | X-ray | 1.72 Å | P/Q/R/Z=4-12 |
| 2KG7 | NMR | B=1-96 |
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