Signal recognition particle subunit SRP68 (SRP68) is a 622-residue protein from Canis lupus familiaris. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q00004.
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The mean pLDDT of this model is 79.1 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 41% |
| 70 to 90 | Confident: backbone generally right | 37% |
| 50 to 70 | Low: treat with caution | 8% |
| Below 50 | Very low: often disordered regions | 14% |
What pLDDT means and how to read it
Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (PubMed:6413076, PubMed:6938958). The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER (PubMed:6413076, PubMed:6938958). The SRP complex targets the ribosome-nascent chain complex to the SRP receptor (SR), which is anchored in the ER, where SR compaction and GTPase rearrangement drive cotranslational protein translocation into the ER (By similarity). Binds the signal recognition particle RNA (7S RNA), SRP72…
Heterodimer with SRP72 (PubMed:6413076, PubMed:8388879). SRP68/SRP72 heterodimer formation is stabilized by the presence of 7SL RNA (PubMed:6413076, PubMed:8388879). Component of a signal recognition particle complex that consists of a 7SL RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9 (PubMed:6413076, PubMed:6938958). Within the SRP complex,…
Cytoplasm, Nucleus, nucleolus, Endoplasmic reticulum
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7OBR | EM | 2.8 Å | u=1-622 |
| 6FRK | EM | 3.7 Å | u=55-622 |
| 6R6G | EM | 3.7 Å | AI=55-249 |
| 7OBQ | EM | 3.9 Å | u=1-622 |
| 4UE5 | EM | 9.0 Å | C=55-249 |
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