Heterokaryon incompatibility protein s (het-s) is a 289-residue protein from Podospora anserina. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q03689.
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The mean pLDDT of this model is 89.6 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 74% |
| 70 to 90 | Confident: backbone generally right | 18% |
| 50 to 70 | Low: treat with caution | 7% |
| Below 50 | Very low: often disordered regions | 1% |
What pLDDT means and how to read it
Responsible for heterokaryon incompatibility, a process that ensures that during spontaneous, vegetative cell fusion only compatible cells from the same colony survive (non-self-recognition). Forms a prion for the non-Mendelian trait [het-s]. Interacts with het-S from incompatible cells to trigger a lethal reaction that prevents the formation of viable heterokaryons. It is unknown if the native, soluble protein has a cellular function
Homodimer. Forms heterodimers with het-S
Cytoplasm
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 2WVQ | X-ray | 2.0 Å | A/B=13-221 |
| 2WVN | X-ray | 2.62 Å | A=1-227 |
| 2KJ3 | NMR | A/B/C=218-289 | |
| 2LBU | NMR | A/B/C/D/E=218-289 | |
| 2MUS | NMR | A/B/C/D/E=218-289 | |
| 2RNM | NMR | A/B/C/D/E=218-289 |
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