Hepatocyte growth factor activator serine protease (HGFAC) is a 655-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q04756.
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The mean pLDDT of this model is 75.3 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 37% |
| 70 to 90 | Confident: backbone generally right | 32% |
| 50 to 70 | Low: treat with caution | 10% |
| Below 50 | Very low: often disordered regions | 21% |
What pLDDT means and how to read it
Serine protease that hydrolyzes the inactive zymogen hepatocyte growth factor (HGFsc) to an activated disulfide-linked heterodimer, then initiating hepatocyte growth factor receptor signaling pathway
Heterodimer of a short chain and a long chain linked by a disulfide bond
Secreted
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 2R0L | X-ray | 2.2 Å | A=408-655, B=373-407 |
| 3K2U | X-ray | 2.35 Å | A=408-655, B=373-407 |
| 1YC0 | X-ray | 2.6 Å | A=373-655 |
| 1YBW | X-ray | 2.7 Å | A/B=373-655 |
| 2WUC | X-ray | 2.7 Å | A=408-654, B=373-407 |
| 2WUB | X-ray | 2.9 Å | A/C=408-655, B/D=373-407 |
| 2R0K | X-ray | 3.51 Å | A=373-655 |
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