Transcription factor RelB (Relb) is a 558-residue protein from Mus musculus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q04863.
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The mean pLDDT of this model is 68.3 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 42% |
| 70 to 90 | Confident: backbone generally right | 10% |
| 50 to 70 | Low: treat with caution | 8% |
| Below 50 | Very low: often disordered regions | 40% |
What pLDDT means and how to read it
NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B…
Component of the NF-kappa-B RelB-p50 complex. Component of the NF-kappa-B RelB-p52 complex (By similarity). Self-associates; the interaction seems to be transient and may prevent degradation allowing for heterodimer formation p50 or p52. Interacts with NFKB1/p50, NFKB2/p52 and NFKB2/p100. Interacts with NFKBID. Interacts with BMAL1 and the interaction is enhanced in the presence of CLOCK
Nucleus, Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 1ZK9 | X-ray | 2.18 Å | A=276-378 |
| 1ZKA | X-ray | 2.2 Å | A=276-378 |
| 4JHB | X-ray | 2.44 Å | A=277-378 |
| 3JUZ | X-ray | 2.51 Å | A=278-378 |
| 3JSS | X-ray | 2.6 Å | A=278-378 |
| 3JV0 | X-ray | 2.65 Å | A=278-378 |
| 3JV6 | X-ray | 2.78 Å | A/C/E=278-378 |
| 4JGM | X-ray | 3.0 Å | A=277-378 |
| 2V2T | X-ray | 3.05 Å | A=91-378 |
| 3DO7 | X-ray | 3.05 Å | A=88-383 |
| 3JV4 | X-ray | 3.15 Å | A/C/E=278-378 |
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