Max dimerization protein 1 (MXD1) is a 221-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q05195.
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The mean pLDDT of this model is 72.6 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 33% |
| 70 to 90 | Confident: backbone generally right | 14% |
| 50 to 70 | Low: treat with caution | 46% |
| Below 50 | Very low: often disordered regions | 8% |
What pLDDT means and how to read it
Component of a transcriptional repressor complex together with MAX (PubMed:8425218). In complex with MAX binds to the core DNA sequence 5'-CAC[GA]TG-3' (PubMed:8425218). Antagonizes MYC transcriptional activity by competing with MYC for MAX binding (PubMed:8425218). Binds to the TERT promoter and represses telomerase expression, possibly by interfering with MYC binding (PubMed:12837246)
Heterodimer with MAX; the interaction is required for DNA-binding (PubMed:8425218). DNA binding requires dimerization with another bHLH protein; does not form homodimers, and does not bind to DNA in the absence of MAX in vitro (PubMed:8425218). Interacts with RNF17 (By similarity)
Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 1NLW | X-ray | 2.0 Å | A/D=57-136 |
| 1E91 | NMR | B=8-20 | |
| 1G1E | NMR | A=6-21 | |
| 1PD7 | NMR | B=5-28 | |
| 1S5Q | NMR | A=6-21 |
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