Membrane-associated protein VP24 (VP24) is a 251-residue protein from Zaire ebolavirus. This is its AlphaFold structure prediction, created 3 Jul 2025. UniProt accession: Q05322.
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The mean pLDDT of this model is 75.9 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 24% |
| 70 to 90 | Confident: backbone generally right | 45% |
| 50 to 70 | Low: treat with caution | 15% |
| Below 50 | Very low: often disordered regions | 15% |
What pLDDT means and how to read it
Prevents the establishment of cellular antiviral state by blocking the interferon-alpha/beta (IFN-alpha/beta) and IFN-gamma signaling pathways. Blocks the IFN-induced nuclear accumulation of host phosphorylated STAT1 by interacting with the STAT1-binding region of host importins. Alternatively also interacts directly with host STAT1 and may additionally inhibit its non-phosphorylated form. Plays a role in assembly of viral nucleocapsid and virion budding. May act as a minor matrix protein that plays a role in assembly of viral nucleocapsid and virion budding
Interacts with host importins KPNA1, KPNA5 and KPNA6 (PubMed:17928350, PubMed:25121748, PubMed:27974555). Interacts with host STAT1 (PubMed:22383882). Interacts with host KEAP1; this interaction activates host transcription factor NRF2 by blocking its interaction with KEAP1 (PubMed:24630991)
Virion membrane, Host cell membrane, Host endomembrane system
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 4M0Q | X-ray | 1.92 Å | A/B=11-237 |
| 4U2X | X-ray | 3.15 Å | A/B/C=16-231 |
| 8Y9J | EM | 4.6 Å | C/D=1-251 |
| 6EHM | EM | 7.3 Å | C/D=1-251 |
| 8UST | EM | 7.3 Å | I/J=1-251 |
| 8USN | EM | 8.9 Å | I/J=1-251 |
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