Transcriptional activator VP30 (VP30) is a 288-residue protein from Zaire ebolavirus. This is its AlphaFold structure prediction, created 3 Jul 2025. UniProt accession: Q05323.
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The mean pLDDT of this model is 63.2 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 18% |
| 70 to 90 | Confident: backbone generally right | 32% |
| 50 to 70 | Low: treat with caution | 15% |
| Below 50 | Very low: often disordered regions | 35% |
What pLDDT means and how to read it
Multifunctional protein that acts as a viral transcriptional activator (PubMed:12163572, PubMed:27279615). Promotes read-through of an RNA hairpin in the NP open reading frame to enhance viral transcription (PubMed:12163572). Mechanistically, nonphosphorylated VP30 hexamers form a ternary complex with the viral leader RNA (PubMed:27315567). Clamps the RNA template and the complex VP35-polymerase L together, thereby increasing the polymerase affinity for the RNA template to increase transcription initiation despite the presence of RNA secondary structures. Also assists stop-start transcription at gene junctions to promote transcription of downstream genes (PubMed:18829754). Interaction with…
Homohexamer; hexamerization is essential for RNA binding (PubMed:27279615). Interacts with the nucleoprotein/NP; this interaction plays both essential and inhibitory roles in viral RNA synthesis (PubMed:28593988). Interacts with VP35 (PubMed:12191476, PubMed:27755595). Interacts with host STAU1 (PubMed:30301857). Interacts (via C-terminus) with host RBBP6 isoform 1 (By similarity). Interacts…
Virion, Host cytoplasm
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 5DVW | X-ray | 1.75 Å | A/B/C/D=142-272 |
| 5T3T | X-ray | 2.2 Å | A/B/C/D/E/F/G/H/I/J=139-288 |
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