Prostaglandin G/H synthase 2 (Ptgs2) is a 604-residue protein from Mus musculus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q05769.
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The mean pLDDT of this model is 92.3 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 91% |
| 70 to 90 | Confident: backbone generally right | 1% |
| 50 to 70 | Low: treat with caution | 2% |
| Below 50 | Very low: often disordered regions | 7% |
What pLDDT means and how to read it
Dual cyclooxygenase and peroxidase in the biosynthesis pathway of prostanoids, a class of C20 oxylipins mainly derived from arachidonate, with a particular role in the inflammatory response (PubMed:12925531, PubMed:20463020, PubMed:20810665, PubMed:21489986, PubMed:22942274). The cyclooxygenase activity oxygenates arachidonate (AA, C20:4(n-6)) to the hydroperoxy endoperoxide prostaglandin G2 (PGG2), and the peroxidase activity reduces PGG2 to the hydroxy endoperoxide PGH2, the precursor of all 2-series prostaglandins and thromboxanes. This complex transformation is initiated by abstraction of hydrogen at carbon 13 (with S-stereochemistry), followed by insertion of molecular O2 to form the…
Homodimer
Microsome membrane, Endoplasmic reticulum membrane, Nucleus inner membrane, Nucleus outer membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 3NT1 | X-ray | 1.73 Å | A/B=18-604 |
| 4PH9 | X-ray | 1.81 Å | A/B=20-568 |
| 5FDQ | X-ray | 1.9 Å | A/B=20-604 |
| 4M10 | X-ray | 2.01 Å | A/B/C/D=18-604 |
| 3HS5 | X-ray | 2.1 Å | A/B=20-604 |
| 3QH0 | X-ray | 2.1 Å | A/B=1-604 |
| 4E1G | X-ray | 2.1 Å | A/B=1-604 |
| 4OTJ | X-ray | 2.11 Å | A/B/C/D=18-604 |
| 3TZI | X-ray | 2.15 Å | A/B=20-604 |
| 8ET0 | X-ray | 2.15 Å | A/B=18-604 |
| 4RUT | X-ray | 2.16 Å | A/B/C/D=18-604 |
| 3NTG | X-ray | 2.19 Å | A/B/C/D=18-569 |
| 3LN0 | X-ray | 2.2 Å | A/B/C/D=18-604 |
| 3MDL | X-ray | 2.2 Å | A/B=20-599 |
| 6OFY | X-ray | 2.2 Å | A/B=20-568 |
| 6BL3 | X-ray | 2.22 Å | A/B/C/D=18-604 |
| 6BL4 | X-ray | 2.22 Å | A/B/C/D=18-604 |
| 3NTB | X-ray | 2.27 Å | A/B/C/D=18-604 |
| 5W58 | X-ray | 2.27 Å | A=18-604 |
| 4Z0L | X-ray | 2.29 Å | A/B/C/D=18-604 |
Showing 20 of 50 experimental structures (best resolution first).
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