Vacuolar protein-sorting-associated protein 36 (VPS36) is a 566-residue protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c). This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q06696.
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The mean pLDDT of this model is 77.6 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 37% |
| 70 to 90 | Confident: backbone generally right | 36% |
| 50 to 70 | Low: treat with caution | 11% |
| Below 50 | Very low: often disordered regions | 16% |
What pLDDT means and how to read it
Component of the ESCRT-II complex, which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs (PubMed:12194858, PubMed:15329733, PubMed:15469844). The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation (PubMed:12194858). The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex (PubMed:12194858). Involved in the trafficking of the plasma membrane ATPase (PubMed:12194858). Its ability to bind ubiquitin plays a central role in endosomal sorting of ubiquitinated cargo proteins by the ESCRT complexes (PubMed:15029239)
Component of the endosomal sorting required for transport complex II (ESCRT-II), which consists of 2 copies of VPS25, 1 copy of SNF8, and 1 copy of VPS36 (PubMed:15329733, PubMed:15469844). The ESCRT-II complex interacts directly with the VPS20 subunit of the ESCRT-III complex (PubMed:12194858). Binds ubiquitin (PubMed:15029239)
Cytoplasm, Endosome membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 2CAY | X-ray | 1.9 Å | A/B=1-103 |
| 2J9U | X-ray | 2.0 Å | B/D=110-171 |
| 1U5T | X-ray | 3.6 Å | B=396-564 |
| 1W7P | X-ray | 3.6 Å | D=1-566 |
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