Peroxiredoxin-1 (PRDX1) is a 199-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q06830.
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The mean pLDDT of this model is 97.2 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 97% |
| 70 to 90 | Confident: backbone generally right | 2% |
| 50 to 70 | Low: treat with caution | 1% |
| Below 50 | Very low: often disordered regions | 1% |
What pLDDT means and how to read it
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2) (PubMed:9497357). Reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation (By similarity)
Homodimer; disulfide-linked, upon oxidation. 5 homodimers assemble to form a ring-like decamer (PubMed:18172504). Interacts with GDPD5; forms a mixed-disulfide with GDPD5 (By similarity). Interacts with SESN1 and SESN2 (PubMed:15105503). Interacts with FAM107A (PubMed:21969592)
Cytoplasm, Melanosome
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 8Z54 | X-ray | 1.45 Å | B=191-199 |
| 8X71 | X-ray | 1.58 Å | A/B=1-175 |
| 8X73 | X-ray | 1.61 Å | A/B=1-175 |
| 9LNH | X-ray | 1.63 Å | A/B=1-175 |
| 9B7A | X-ray | 1.71 Å | A/B=1-175 |
| 7WET | X-ray | 1.76 Å | A/B=1-175 |
| 7WEU | X-ray | 1.81 Å | A/B=1-175 |
| 8Z56 | X-ray | 1.81 Å | B=191-199 |
| 9LG0 | X-ray | 1.81 Å | A/B=1-175 |
| 8Z55 | X-ray | 1.83 Å | B=191-199 |
| 8Z57 | X-ray | 1.96 Å | B=191-199 |
| 3HY2 | X-ray | 2.1 Å | A/B=1-199 |
| 4XCS | X-ray | 2.1 Å | A/B/C/D/E/F=1-199 |
| 9DEX | X-ray | 2.3 Å | A/B=2-199 |
| 8Z58 | X-ray | 2.4 Å | B=191-199 |
| 2RII | X-ray | 2.6 Å | A/B=1-199 |
| 7LJ1 | X-ray | 2.97 Å | A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T=1-199 |
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