Q07440: Bcl-2-related protein A1 (Bcl2a1)

Bcl-2-related protein A1 (Bcl2a1) is a 172-residue protein from Mus musculus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q07440.

Gene
Bcl2a1
Organism
Mus musculus
Length
172 residues
Mean pLDDT
86.1
Model
AF-Q07440-F1 v6
Model created
1 Aug 2025
PDB structures
4

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Model confidence (pLDDT)

The mean pLDDT of this model is 86.1 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.

pLDDT bandMeaningShare of residues
Above 90Very high: backbone and side chains are usually accurate61%
70 to 90Confident: backbone generally right20%
50 to 70Low: treat with caution19%
Below 50Very low: often disordered regions0%

What pLDDT means and how to read it

Function

Retards apoptosis induced by IL-3 deprivation. May function in the response of hemopoietic cells to external signals and in maintaining endothelial survival during infection. Can inhibit apoptosis induced by serum starvation in the mammary epithelial cell line HC11 (PubMed:11888890)

Subunit structure

Interacts directly with BCL2L11/BIM and PMAIP1 (By similarity). Interacts directly with BAK1, BID, BMF and BBC3. Interacts with BOP (By similarity). Interacts with isoform 3, isoform 4 and isoform 5 of ING4. Interacts with UBQLN4 (By similarity)

Subcellular location

Cytoplasm

Experimental structures in the PDB

Compare the prediction with experimentally determined structures of the same protein:

PDB IDMethodResolutionChains and residues
2VOFX-ray1.8 ÅA/C=1-152
2VOGX-ray1.9 ÅA=1-152
2VOHX-ray1.9 ÅA=1-152
2VOIX-ray2.1 ÅA=1-152

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