Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) is a 350-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q07820.
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The mean pLDDT of this model is 63.6 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 29% |
| 70 to 90 | Confident: backbone generally right | 14% |
| 50 to 70 | Low: treat with caution | 10% |
| Below 50 | Very low: often disordered regions | 47% |
What pLDDT means and how to read it
Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis
Interacts with HIF3A (via C-terminus domain) (By similarity). Interacts with BAD, BOK, BIK and BMF (By similarity). Interacts with PMAIP1 (PubMed:17389404). Interacts with BBC3 (By similarity). Isoform 1 interacts with BAX, BAK1 and TPT1 (PubMed:10837489, PubMed:12149273, PubMed:15077116). Heterodimer of isoform 1 and isoform 2. Homodimers of isoform 1 or isoform 2 are not detected. Isoform 2…
Membrane, Cytoplasm, Mitochondrion, Nucleus, nucleoplasm
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 8VJP | X-ray | 1.13 Å | A=172-323 |
| 9PQ7 | X-ray | 1.24 Å | A=173-321 |
| 9PQ5 | X-ray | 1.28 Å | A=173-321 |
| 6UDV | X-ray | 1.35 Å | A=171-327 |
| 9UGP | X-ray | 1.39 Å | A=171-322 |
| 8G3S | X-ray | 1.4 Å | A=173-321 |
| 5W89 | X-ray | 1.42 Å | A=172-321 |
| 5C3F | X-ray | 1.43 Å | A=173-327 |
| 8G3X | X-ray | 1.46 Å | A=173-321 |
| 8H7B | X-ray | 1.46 Å | A/B=172-322 |
| 8SVY | X-ray | 1.47 Å | A=173-321 |
| 6OQD | X-ray | 1.48 Å | A=171-327 |
| 5FC4 | X-ray | 1.5 Å | A=172-320 |
| 6UDT | X-ray | 1.5 Å | A=171-327 |
| 4HW4 | X-ray | 1.53 Å | A/B=172-327 |
| 9PQ6 | X-ray | 1.53 Å | A=173-321 |
| 2NL9 | X-ray | 1.55 Å | A=209-327 |
| 4WMU | X-ray | 1.55 Å | A=174-321 |
| 6UA3 | X-ray | 1.55 Å | A=172-325 |
| 8EKX | X-ray | 1.55 Å | A=173-321 |
Showing 20 of 143 experimental structures (best resolution first).
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