Histone-binding protein RBBP4 (RBBP4) is a 425-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q09028.
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The mean pLDDT of this model is 91.7 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 86% |
| 70 to 90 | Confident: backbone generally right | 4% |
| 50 to 70 | Low: treat with caution | 4% |
| Below 50 | Very low: often disordered regions | 7% |
What pLDDT means and how to read it
Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA (PubMed:10866654). Component of the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair (PubMed:8858152). Component of the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression (PubMed:9150135). Component of the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation…
Binds directly to helix 1 of the histone fold of histone H4, a region that is not accessible when H4 is in chromatin (PubMed:24920672, PubMed:8858152, PubMed:9427644). Subunit of the chromatin assembly factor 1 (CAF-1) complex, which is composed of RBBP4, CHAF1B and CHAF1A (PubMed:8858152). Subunit of the core histone deacetylase (HDAC) complex, which is composed of HDAC1, HDAC2, RBBP4 and RBBP7…
Nucleus, Chromosome, telomere
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 4R7A | X-ray | 1.85 Å | B=1-425 |
| 7M40 | X-ray | 1.88 Å | A/B=1-425 |
| 2XU7 | X-ray | 1.9 Å | A/B=1-425 |
| 5XXQ | X-ray | 1.9 Å | A/B=1-425 |
| 6BW4 | X-ray | 2.0 Å | A/C=1-425 |
| 5Y1U | X-ray | 2.14 Å | A/B=1-425 |
| 4PBZ | X-ray | 2.15 Å | A=1-425 |
| 6BW3 | X-ray | 2.2 Å | A/C=1-425 |
| 8TX8 | X-ray | 2.2 Å | A/B=1-425 |
| 3GFC | X-ray | 2.3 Å | A=1-425 |
| 5VTB | X-ray | 2.4 Å | A=1-425 |
| 4PBY | X-ray | 2.5 Å | A/B=1-425 |
| 4PC0 | X-ray | 2.5 Å | A/B=1-425 |
| 6ZRD | X-ray | 2.5 Å | A/B=1-425 |
| 7N40 | X-ray | 2.55 Å | A=1-425 |
| 6ZRC | X-ray | 2.6 Å | A/B=1-425 |
| 5XWR | X-ray | 2.69 Å | A/B=1-425 |
| 9XZI | X-ray | 2.69 Å | B=1-425 |
| 6G16 | X-ray | 2.8 Å | A/C/E/G=1-425 |
| 6NQ3 | X-ray | 2.89 Å | A/E=1-425 |
Showing 20 of 49 experimental structures (best resolution first).
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