Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2) is a 320-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q13155.
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The mean pLDDT of this model is 81.1 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 58% |
| 70 to 90 | Confident: backbone generally right | 15% |
| 50 to 70 | Low: treat with caution | 13% |
| Below 50 | Very low: often disordered regions | 13% |
What pLDDT means and how to read it
Required for assembly and stability of the aminoacyl-tRNA synthase complex (PubMed:19131329). Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down-regulation which is required for aveolar type II cell differentiation. Blocks MDM2-mediated ubiquitination and degradation of p53/TP53. Functions as a proapoptotic factor
Part of the multisynthetase complex (MSC), a multisubunit complex that groups tRNA ligases for Arg (RARS1), Asp (DARS1), Gln (QARS1), Ile (IARS1), Leu (LARS1), Lys (KARS1), Met (MARS1) the bifunctional ligase for Glu and Pro (EPRS1) and the auxiliary subunits AIMP1/p43, AIMP2/p38 and EEF1E1/p18 (PubMed:19131329, PubMed:19289464, PubMed:24312579). Interacts (via N-terminus) with KARS1…
Cytoplasm, cytosol, Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6K39 | X-ray | 1.4 Å | A/B=25-32 |
| 6ILD | X-ray | 1.88 Å | C=1-36 |
| 4YCU | X-ray | 2.1 Å | C=1-36 |
| 5A1N | X-ray | 2.1 Å | B=90-320 |
| 6JPV | X-ray | 2.15 Å | A/B=24-32 |
| 5A5H | X-ray | 2.32 Å | B/D/F/H=90-320 |
| 5A34 | X-ray | 2.6 Å | B/D/F/H=90-320 |
| 9DPL | EM | 2.8 Å | D/E=1-36 |
| 4DPG | X-ray | 2.84 Å | I/J/K/L=1-48 |
| 4YCW | X-ray | 2.9 Å | C/D/G/H=1-36 |
| 5Y6L | X-ray | 2.9 Å | D=90-320 |
| 8J9S | X-ray | 3.01 Å | C=51-90 |
| 6IY6 | X-ray | 3.6 Å | C/D/I/J=115-320 |
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