Mitogen-activated protein kinase 7 (MAPK7) is a 816-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q13164.
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The mean pLDDT of this model is 65.1 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 33% |
| 70 to 90 | Confident: backbone generally right | 12% |
| 50 to 70 | Low: treat with caution | 12% |
| Below 50 | Very low: often disordered regions | 43% |
What pLDDT means and how to read it
Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras-independent and MAP2K5-dependent pathway. As part of the MAPK/ERK signaling pathway, acts as a negative regulator of apoptosis in cardiomyocytes via interaction with STUB1/CHIP and promotion of STUB1-mediated ubiquitination and degradation of ICER-type isoforms of CREM (By similarity). May have a role in muscle cell differentiation. May be important for endothelial function and maintenance…
Interacts with MAP2K5. Forms oligomers (By similarity). Interacts with MEF2A, MEF2C and MEF2D; the interaction phosphorylates the MEF2s and enhances transcriptional activity of MEF2A, MEF2C but not MEF2D (By similarity). Interacts with SGK1. Preferentially interacts with PML isoform PML-4 but shows interaction also with its other isoforms: isoform PML-1, isoform PML-2, isoform PML-3 and isoform…
Cytoplasm, Nucleus, Nucleus, PML body
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 5BYZ | X-ray | 1.65 Å | A=48-395 |
| 4ZSG | X-ray | 1.79 Å | A=47-393 |
| 2Q8Y | X-ray | 2.0 Å | B=215-223 |
| 4ZSL | X-ray | 2.25 Å | A=53-393 |
| 6HKN | X-ray | 2.33 Å | A=54-393 |
| 9LTA | X-ray | 2.33 Å | A/B=48-393 |
| 5O7I | X-ray | 2.38 Å | A=46-402 |
| 6HKM | X-ray | 2.47 Å | A=49-395 |
| 4ZSJ | X-ray | 2.48 Å | A=50-393 |
| 7PUS | X-ray | 2.59 Å | AAA=46-402 |
| 4IC7 | X-ray | 2.6 Å | A/D=1-431 |
| 5BYY | X-ray | 2.79 Å | A=49-394 |
| 4B99 | X-ray | 2.8 Å | A=1-397 |
| 4IC8 | X-ray | 2.8 Å | A/B=1-431 |
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