C-terminal-binding protein 1 (CTBP1) is a 440-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q13363.
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The mean pLDDT of this model is 83.3 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 74% |
| 70 to 90 | Confident: backbone generally right | 1% |
| 50 to 70 | Low: treat with caution | 2% |
| Below 50 | Very low: often disordered regions | 23% |
What pLDDT means and how to read it
Corepressor targeting diverse transcription regulators such as GLIS2 or BCL6. Has dehydrogenase activity. Involved in controlling the equilibrium between tubular and stacked structures in the Golgi complex. Functions in brown adipose tissue (BAT) differentiation
Homo- or heterodimer. Heterodimer with CTBP2. Interacts with PRDM16; the interaction represses white adipose tissue (WAT)-specific genes expression. Interacts with GLIS2, FOXP2, HDAC4, HDAC5, HDAC9 and ZNF217. Interacts with ELK3 (via its PXDLS motif). Interacts with RBBP8 (via its PXDLS motif); the interaction is disrupted by binding to adenovirus E1A. Interacts with FOXP1, HIPK2, PNN, NRIP1,…
Cytoplasm, Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 1MX3 | X-ray | 1.95 Å | A=28-353 |
| 4U6S | X-ray | 2.1 Å | A=28-353 |
| 9WRJ | X-ray | 2.2 Å | A=28-378 |
| 4U6Q | X-ray | 2.3 Å | A=28-353 |
| 7KWM | X-ray | 2.3 Å | A=28-356 |
| 6V8A | X-ray | 2.35 Å | A=28-375 |
| 4LCE | X-ray | 2.38 Å | A=28-353 |
| 6CDR | X-ray | 2.4 Å | A=28-379 |
| 6V89 | X-ray | 2.45 Å | A=28-375 |
| 6CDF | X-ray | 2.6 Å | A=28-379 |
| 8ARI | EM | 3.0 Å | A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/X=1-440 |
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