Short transient receptor potential channel 3 (TRPC3) is a 921-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q13507.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 78.3 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 40% |
| 70 to 90 | Confident: backbone generally right | 37% |
| 50 to 70 | Low: treat with caution | 5% |
| Below 50 | Very low: often disordered regions | 17% |
What pLDDT means and how to read it
Forms a receptor-activated non-selective calcium permeant cation channel (PubMed:29726814, PubMed:30139744, PubMed:35051376, PubMed:9417057, PubMed:9930701, PubMed:10611319)
Homotetramer (PubMed:29700422, PubMed:29726814, PubMed:30139744, PubMed:35051376). Interacts with ITPR1 (PubMed:9853757). Interacts with ITPR3 (PubMed:10611319). Interacts with MX1 (PubMed:15757897). Interacts with RNF24 (PubMed:17850865). Interacts with JPH2; the interaction is involved in maintaining Ca(2+) homeostasis in skeletal muscle and is mediated by JPH2 'Ser-165' phosphorylation…
Cell membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 9U5C | EM | 2.25 Å | A/C/E/G=86-921 |
| 9OLM | EM | 2.5 Å | A/B/C/D=74-911 |
| 9KDB | EM | 2.67 Å | A/B/C/D=1-921 |
| 7DXB | EM | 2.7 Å | A/B/C/D=86-921 |
| 9KDD | EM | 2.7 Å | A/B/C/D=1-921 |
| 9VFI | EM | 2.72 Å | A/B/C/D=86-921 |
| 9OLK | EM | 2.8 Å | A/B/C/D=74-921 |
| 9KDC | EM | 3.01 Å | A/B/C/D=1-921 |
| 7DXC | EM | 3.06 Å | A/B/C/D=86-921 |
| 9OLL | EM | 3.1 Å | A/B/C/D=74-921 |
| 7DXE | EM | 3.2 Å | A/B/C/D=86-921 |
| 6CUD | EM | 3.3 Å | A/B/C/D=86-891 |
| 9OLX | EM | 3.3 Å | A/B/C/D=74-911 |
| 9OPU | EM | 3.3 Å | A/B/C/D=74-911 |
| 9KDE | EM | 3.34 Å | A/B/C/D=1-921 |
| 7DXD | EM | 3.9 Å | A/B/C/D=86-921 |
| 6D7L | EM | 4.0 Å | A/B/C/D=73-921 |
| 5ZBG | EM | 4.36 Å | A/B/C/D=86-921 |
| 6DJS | EM | 5.8 Å | A/B/C/D=73-384, A/B/C/D=846-921 |
MolViewer loads the AlphaFold model straight from AlphaFold DB into your browser. Show it as a cartoon, color by pLDDT, measure distances and angles, and load a PDB structure next to it to compare.