Apoptosis-stimulating of p53 protein 2 (TP53BP2) is a 1128-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q13625.
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The mean pLDDT of this model is 59.0 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 18% |
| 70 to 90 | Confident: backbone generally right | 22% |
| 50 to 70 | Low: treat with caution | 7% |
| Below 50 | Very low: often disordered regions | 53% |
What pLDDT means and how to read it
Regulator that plays a central role in regulation of apoptosis and cell growth via its interactions with proteins such as TP53 (PubMed:12524540). Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. Inhibits the ability of NAE1 to conjugate NEDD8 to CUL1, and thereby decreases NAE1 ability to induce apoptosis. Impedes cell cycle progression at G2/M. Its apoptosis-stimulating activity is inhibited by its interaction with DDX42
Interacts with P53/TP53; the interaction promotes pro-apoptotic activity (PubMed:11684014, PubMed:12524540, PubMed:8016121). Interacts with BCL2 (PubMed:8668206). Interacts with protein phosphatase 1. Interacts with RELA NF-kappa-B subunit. This interaction probably prevents the activation of apoptosis, possibly by preventing its interaction with TP53. Interacts with APC2 and NAE1. Interacts…
Cytoplasm, perinuclear region, Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6HKP | X-ray | 1.9 Å | S=970-992 |
| 4IRV | X-ray | 2.04 Å | E/F/G/H=726-782 |
| 6GHM | X-ray | 2.15 Å | C/D=920-1128 |
| 1YCS | X-ray | 2.2 Å | B=892-1128 |
| 4A63 | X-ray | 2.27 Å | B/D/F/H/J/L=892-1128 |
| 2UWQ | NMR | A=1-83 |
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