Protein patched homolog 1 (PTCH1) is a 1447-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q13635.
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The mean pLDDT of this model is 73.9 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 43% |
| 70 to 90 | Confident: backbone generally right | 27% |
| 50 to 70 | Low: treat with caution | 3% |
| Below 50 | Very low: often disordered regions | 27% |
What pLDDT means and how to read it
Negative regulator of the smoothened signaling pathway, which acts as a receptor for hedgehog (SHH, IHH and DHH) morphogens (PubMed:21537345, PubMed:29954986, PubMed:29995851, PubMed:30139912, PubMed:31127104, PubMed:31555730, PubMed:37611095, PubMed:40128518, PubMed:9811851). In absence of hedgehog, acts as an inhibitor of smoothened protein (SMO) by preventing SMO access to cholesterol: mechanistically, acts as a cholesterol transporter, which depeletes cholesterol from the outer leaflet of plasma membrane, thereby preventing cholesterol-binding to the extracellular CRD region of SMO (PubMed:31555730, PubMed:37611095). Hedgehog-binding inhibits PTCH1 cholesterol transporter activity,…
Homodimer; two PTCH1 molecules engage one hedgehog (SHH, IHH and DHH) molecule (PubMed:30139912). Interacts with SNX17 (PubMed:15769472). Interacts with G protein-coupled receptor GPR37L1 (By similarity). Interacts with CAV1 (PubMed:11278759)
Cell membrane, Cell projection, cilium membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6RTW | X-ray | 1.9 Å | A=136-423 |
| 6RTX | X-ray | 1.95 Å | A=139-428 |
| 6RTY | X-ray | 2.1 Å | A=136-423 |
| 6RVC | X-ray | 2.2 Å | A/B/C=772-1023 |
| 6RMG | EM | 3.4 Å | A=1-1188 |
| 6E1H | EM | 3.5 Å | A/B=1-1447 |
| 6OEU | EM | 3.5 Å | A=1-1447 |
| 6RVD | EM | 3.5 Å | A/B=1-1447 |
| 6DMY | EM | 3.6 Å | A=1-1305 |
| 6N7H | EM | 3.6 Å | A/B=1-1305 |
| 9MS8 | EM | 3.73 Å | A=1-1188 |
| 6OEV | EM | 3.8 Å | A=1-1447 |
| 6DMB | EM | 3.9 Å | A=1-1305 |
| 6DMO | EM | 4.1 Å | A=1-1305 |
| 6N7K | EM | 6.5 Å | A/B/D/E=1-1305 |
| 6N7G | EM | 6.8 Å | A/B/D/E=1-1305 |
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