MORC family CW-type zinc finger protein 3 (MORC3) is a 939-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q14149.
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The mean pLDDT of this model is 71.2 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 35% |
| 70 to 90 | Confident: backbone generally right | 28% |
| 50 to 70 | Low: treat with caution | 10% |
| Below 50 | Very low: often disordered regions | 28% |
What pLDDT means and how to read it
Nuclear matrix protein which forms MORC3-NBs (nuclear bodies) via an ATP-dependent mechanism and plays a role in innate immunity by restricting different viruses through modulation of the IFN response (PubMed:27440897, PubMed:34759314). Mechanistically, possesses a primary antiviral function through a MORC3-regulated element that activates IFNB1, and this function is guarded by a secondary IFN-repressing function (PubMed:34759314). Sumoylated MORC3-NBs associates with PML-NBs and recruits TP53 and SP100, thus regulating TP53 activity (PubMed:17332504, PubMed:20501696). Binds RNA in vitro (PubMed:11927593). Histone methylation reader which binds to non-methylated (H3K4me0), monomethylated…
Homodimer (PubMed:17332504, PubMed:30850548). The sumoylated form interacts with PML (via SUMO-interacting motif) (PubMed:17332504, PubMed:20501696). Interacts with TP53 (PubMed:17332504)
Nucleus, nucleoplasm, Nucleus matrix, Nucleus, PML body, Chromosome
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 5SVY | X-ray | 1.05 Å | A=407-455 |
| 6O5W | X-ray | 1.41 Å | A=407-455 |
| 5SVX | X-ray | 1.56 Å | A=407-454 |
| 5SVI | X-ray | 1.61 Å | A/B=407-454 |
| 4QQ4 | X-ray | 1.75 Å | A/B=400-460 |
| 6O1E | X-ray | 2.41 Å | A=1-455 |
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