Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 (ACAP1) is a 740-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q15027.
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The mean pLDDT of this model is 84.4 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 65% |
| 70 to 90 | Confident: backbone generally right | 20% |
| 50 to 70 | Low: treat with caution | 4% |
| Below 50 | Very low: often disordered regions | 11% |
What pLDDT means and how to read it
GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6) required for clathrin-dependent export of proteins from recycling endosomes to trans-Golgi network and cell surface. Required for regulated export of ITGB1 from recycling endosomes to the cell surface and ITGB1-dependent cell migration
Banana-shaped homodimer laterally assembling into tetramers, the tetramers further pack helically onto the membrane. Interacts with GTP-bound ARF6. Interacts with third cytoplasmic loop of SLC2A4/GLUT4. Interacts with CLTC. Interacts with GULP1. Forms a complex with GDP-bound ARF6 and GULP1. Interacts with ITGB1; required for ITGB1 recycling
Recycling endosome membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 4NSW | X-ray | 2.2 Å | A/B=1-377 |
| 3JUE | X-ray | 2.3 Å | A/B=378-740 |
| 3T9K | X-ray | 2.3 Å | A/B=378-740 |
| 4F1P | X-ray | 2.3 Å | A/B=378-740 |
| 4CKG | EM | 12.0 Å | A/B/C/D=1-377 |
| 4CKH | EM | 14.0 Å | A/B/C/D=1-377 |
| 5H3D | EM | 14.0 Å | A/B/C/D=1-377 |
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