DNA polymerase delta subunit 3 (POLD3) is a 466-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q15054.
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The mean pLDDT of this model is 63.1 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 31% |
| 70 to 90 | Confident: backbone generally right | 6% |
| 50 to 70 | Low: treat with caution | 15% |
| Below 50 | Very low: often disordered regions | 48% |
What pLDDT means and how to read it
Accessory component of both the DNA polymerase delta complex and the DNA polymerase zeta complex (PubMed:17317665, PubMed:22801543, PubMed:24449906). As a component of the trimeric and tetrameric DNA polymerase delta complexes (Pol-delta3 and Pol-delta4, respectively), plays a role in high fidelity genome replication, including in lagging strand synthesis, and repair. Required for optimal Pol-delta activity. Stabilizes the Pol-delta complex and plays a major role in Pol-delta stimulation by PCNA (PubMed:10219083, PubMed:10852724, PubMed:11595739, PubMed:16510448, PubMed:24035200). Pol-delta3 and Pol-delta4 are characterized by the absence or the presence of POLD4. They exhibit differences…
Component of both the DNA polymerase delta and DNA polymerase zeta complexes (PubMed:17317665, PubMed:22801543, PubMed:24449906). The tetrameric DNA polymerase delta complex (Pol-delta4), which consists of POLD1/p125, POLD2/p50, POLD3/p66/p68 and POLD4/p12, with POLD1 bearing DNA polymerase and 3' to 5' proofreading exonuclease activities (PubMed:11328591, PubMed:11595739, PubMed:17317665,…
Cytoplasm, Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 1U76 | X-ray | 2.6 Å | B/D/F=452-466 |
| 3E0J | X-ray | 3.0 Å | B/D/F/H=1-144 |
| 6TNY | EM | 3.08 Å | C=2-466 |
| 9EKB | EM | 3.65 Å | C=1-466 |
| 6TNZ | EM | 4.05 Å | C=2-466 |
| 6S1M | EM | 4.27 Å | C=2-466 |
| 6S1N | EM | 4.86 Å | C=2-466 |
| 6S1O | EM | 8.1 Å | C=2-466 |
| 2N1G | NMR | B=231-246 |
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